ArticleJournal of neurochemistry2010
Evidence for coupling between steady-state and dynamic extracellular dopamine concentrations in the rat striatum.
Article in Journal of neurochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Neuromodulatory control of energy reserves in dopaminergic neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- In vivo evidence for the unique kinetics of evoked dopamine release in the patch and matrix compartments of the striatum.Analytical and bioanalytical chemistry · 2021Article
- Kinetic diversity of dopamine transmission in the dorsal striatum.Journal of neurochemistry · 2015Article
- Understanding the role α7 nicotinic receptors play in dopamine efflux in nucleus accumbens.ACS chemical neuroscience · 2014Article
- A novel restricted diffusion model of evoked dopamine.ACS chemical neuroscience · 2014Review
- Voltammetric and mathematical evidence for dual transport mediation of serotonin clearance in vivo.Journal of neurochemistry · 2014Article
- Region- and domain-dependent action of nomifensine.The European journal of neuroscience · 2014Article
- The dopamine patchwork of the rat nucleus accumbens core.The European journal of neuroscience · 2013Article
- Restricted diffusion of dopamine in the rat dorsal striatum.ACS chemical neuroscience · 2013Article
- A method for the intracranial delivery of reagents to voltammetric recording sites.Journal of neuroscience methods · 2012Article
- Domain-dependent effects of DAT inhibition in the rat dorsal striatum.Journal of neurochemistry · 2012Article
- Microdialysis probes alter presynaptic regulation of dopamine terminals in rat striatum.Journal of neuroscience methods · 2012Article
- Effect of dexamethasone on gliosis, ischemia, and dopamine extraction during microdialysis sampling in brain tissue.Analytical chemistry · 2011Article
- An inverse correlation between the apparent rate of dopamine clearance and tonic autoinhibition in subdomains of the rat striatum: a possible role of transporter-mediated dopamine efflux.Journal of neurochemistry · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A previous study from our laboratory demonstrated the presence within the rat striatum of dopaminergic terminals in different dynamical states, determined at least in part by the extent to which terminals are subject to autoinhibition. The present study is designed to test the hypothesis that heterogeneity in the basal tonic extracellular dopamine concentration contributes to the variable extent of autoinhibition. We probed basal extracellular dopamine concentrations using a previously demonstrated strategy that utilizes intrastriatal microinfusion of kynurenate, a substance that according to voltammetric measurements decreases extracellular dopamine from its basal concentration. In the striatum, however, we find that the response to kynurenate infusion is itself heterogeneous, allowing a broad classification of sites within the striatum as kynurenate-insensitive and kynurenate-sensitive, respectively. These newly identified kynurenate-insensitive and sensitive sites yield substantially and significantly different evoked dopamine release as measured by voltammetry during electrical stimulation of the medial forebrain bundle. Our findings confirm the hypothesis that heterogeneity in the local basal concentration of dopamine is responsible for the variable extent of autoinhibition within the striatum and support the conclusion that the steady state and dynamical components of extracellular dopamine in this brain region are coupled.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.