ArticleFEMS immunology and medical microbiology2010
Role of spx in biofilm formation of Staphylococcus epidermidis.
Article in FEMS immunology and medical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- The pathogenicity and virulence of the opportunistic pathogenVirulence · 2024Review
- The first genomic characterization of a stable, hemin-dependent small colony variant strain ofFrontiers in microbiology · 2023Article
- Cellular functions of the ClpP protease impacting bacterial virulence.Frontiers in molecular biosciences · 2022Review
- Article
- Inactivation ofJournal of bacteriology · 2019Article
- Roles and regulation of Spx family transcription factors in Bacillus subtilis and related species.Advances in microbial physiology · 2019Review
- Induction of the Spx regulon by cell wall stress reveals novel regulatory mechanisms in Bacillus subtilis.Molecular microbiology · 2018Article
- Genetic Adaptation of a Mevalonate Pathway Deficient Mutant inFrontiers in microbiology · 2018Article
- Inactivation of the spxA1 or spxA2 gene of Streptococcus mutans decreases virulence in the rat caries model.Molecular oral microbiology · 2017Article
- Identification of Genes Controlled by the Essential YycFG Two-Component System Reveals a Role for Biofilm Modulation inFrontiers in microbiology · 2017Article
- Transcription of Oxidative Stress Genes Is Directly Activated by SpxA1 and, to a Lesser Extent, by SpxA2 in Streptococcus mutans.Journal of bacteriology · 2015Article
- Thiol-based redox switches in prokaryotes.Biological chemistry · 2015Review
- Anti-Biofilm Activities from Marine Cold Adapted Bacteria Against Staphylococci and Pseudomonas aeruginosa.Frontiers in microbiology · 2015Article
- Clinical characteristics of Staphylococcus epidermidis: a systematic review.GMS hygiene and infection control · 2014Review
- Genome-wide identification of genes directly regulated by the pleiotropic transcription factor Spx in Bacillus subtilis.Nucleic acids research · 2012Article
- Bacterial proteolytic complexes as therapeutic targets.Nature reviews. Drug discovery · 2012Review
- Genetic regulation of the intercellular adhesion locus in staphylococci.Frontiers in cellular and infection microbiology · 2012Review
- The eukaryotic-type serine/threonine protein kinase Stk is required for biofilm formation and virulence in Staphylococcus epidermidis.PloS one · 2011Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Infections caused by the leading nosocomial pathogen Staphylococcus epidermidis are characterized by biofilm formation on implanted medical devices. In a previous study, we found that ClpP protease plays an essential role in biofilm formation of S. epidermidis. However, the mechanism by which ClpP impacts S. epidermidis biofilms has remained unknown. Here, we show that the Spx protein accumulates in the clpP mutant strain of S. epidermidis and controls biofilm formation of S. epidermidis via a pronounced effect on the transcription of the icaADBC operon coding for the production of the biofilm exopolysaccharide polysaccharide intercellular adhesion (PIA). Notably, in contrast to Staphylococcus aureus, Spx controls PIA expression via an icaR-independent mechanism. Furthermore, Spx affected primary surface attachment, although not by regulating the production of the autolysin AtlE. Our results indicate that ClpP enhances the formation of S. epidermidis biofilms by degrading Spx, a negative regulator of biofilm formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.