ReviewEnvironmental health perspectives1991
Lead in bone: implications for toxicology during pregnancy and lactation.
Review in Environmental health perspectives, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 310 citations in OpenAlex.
- Lead and arsenic intoxications by traditional and alternative medicine: men are more sensitive than women.Naunyn-Schmiedeberg's archives of pharmacology · 2025Pooled it
- Dentine markers of pre/early postnatal lead exposure links with brain, cognitive, and behavioral outcomes in adolescents.medRxiv : the preprint server for health sciences · 2026Article
- Estrogen-containing contraceptive use and blood lead concentrations in a cohort of premenopausal individuals.Environmental research · 2025Article
- Association between bone trace metal accumulation and idiopathic aseptic osteonecrosis of the femoral head in a mining region of Katanga (DR Congo).Journal of orthopaedic surgery and research · 2025Article
- Evaluation of Heavy Metals and Essential Minerals in the Hair of Children with Autism Spectrum Disorder and Their Association with Symptom Severity.Biological trace element research · 2025Article
- Comprehensive Profiling of Essential Elements and Organic and Inorganic Contaminants in Dromedary Camels from the Canary Islands: A Baseline for Nutritional and Environmental Assessment.Veterinary sciences · 2025Article
- Sex dependent intergenerational effects of lead in mouse model.Scientific reports · 2024Article
- A Multigenerational Model of Environmental Risk for Black, Indigenous, and People of Color (BIPOC) Children and Families.Environmental health perspectives · 2024Article
- Blood Lead Levels among Non-Occupationally Exposed Pregnant Women in Southern Thailand.Toxics · 2022Article
- Chronic exposure to lead acetate promotes changes in the alveolar bone of rats: microstructural and physical-chemical characterization.Environmental science and pollution research international · 2022Article
- Patterns and Determinants of Essential and Toxic Elements in Chinese Women at Mid-Pregnancy, Late Pregnancy, and Lactation.Nutrients · 2021Article
- DNA methylation at birth potentially mediates the association between prenatal lead (Pb) exposure and infant neurodevelopmental outcomes.Environmental epigenetics · 2021Article
- Assessment of a Screening Questionnaire to Identify Exposure to Lead in Pregnant Women.International journal of environmental research and public health · 2020Article
- Estimating the causal effect of prenatal lead exposure on prepulse inhibition deficits in children and adolescents.Neurotoxicology · 2020Article
- Trimester-Specific Associations of Prenatal Lead Exposure With Infant Cord Blood DNA Methylation at Birth.Epigenetics insights · 2020Article
- The pathway of lead through the mother's body to the child.Interdisciplinary toxicology · 2019Review
- Article
- Neurotoxicity of low-level lead exposure: History, mechanisms of action, and behavioral effects in humans and preclinical models.Neurotoxicology · 2019Review
- Lead Poisoning and Intelligence: A Search for Cause and Effect in the Scottish Mental Surveys.Journal of environmental and public health · 2019Review
- Assessment of the LeadCare® Plus for Use on Scandinavian Brown BearsFrontiers in veterinary science · 2019Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advances in understanding the distribution and retention of lead in mineralized tissues are important for two reasons: first, bone lead may be a more accurate dosimeter of integrated absorption associated with chronic exposures, and second, bone lead may be a source of internal exposure to the host organism. Little attention has been paid to this second aspect, the remobilization of lead from bone. Mobilization of lead from bone is likely to occur during periods of altered mineral metabolism; since calciotropic factors determine the uptake and storage of lead in this compartment, changes in calcium-related regulatory factors are likely to affect lead compartmentation. Calcium metabolism changes drastically in humans during pregnancy and lactation; although relatively little is known of lead kinetics during these critical periods, it is likely that bone lead is mobilized and transferred to the more bioavailable compartment of the maternal circulation, with potential toxic effects on the fetus and the mother.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.