ArticleBehavior genetics2010
Lifestyle modifies the relationship between body composition and adrenergic receptor genetic polymorphisms, ADRB2, ADRB3 and ADRA2B: a secondary analysis of a randomized controlled trial of physical activity among postmenopausal women.
Article in Behavior genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- High genetic risk individuals benefit less from resistance exercise intervention.International journal of obesity (2005) · 2015Trial
- Effects of the Trp64Arg Polymorphism in theGenes · 2023Article
- Comparison of visceral fat lipolysis adaptation to high-intensity interval training in obesity-prone and obesity-resistant rats.Diabetology & metabolic syndrome · 2022Article
- An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training-induced muscle fiber hypertrophy in younger men.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Individual Responsiveness to Exercise-Induced Fat Loss and Improvement of Metabolic Profile in Young Women is Associated with Polymorphisms of Adrenergic Receptor Genes.Journal of sports science & medicine · 2018Article
- Genetic Variant in ACVR2B Is Associated with Lean Mass.Medicine and science in sports and exercise · 2016Observational
- Beta-3-adrenergic receptor Trp64Arg polymorphism: does it modulate the relationship between exercise and percentage of body fat in young adult Japanese males?Environmental health and preventive medicine · 2013Article
- Genetic Influences on Physiological and Subjective Responses to an Aerobic Exercise Session among Sedentary Adults.Journal of cancer epidemiology · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Genetic variations in the adrenergic receptor (ADR) have been associated with body composition in cross-sectional studies. Recent findings suggest that ADR variants may also modify body composition response to lifestyle. We assessed the role of ADR variants in body composition response to 12 months of resistance training versus control in previously sedentary postmenopausal women. Randomized trial completers were genotyped for A2B (Glu9/12) by fragment length analysis, and B2 (Gln27Glu) and B3 (Trp64Arg) by TaqMan (n = 148, 54% hormone therapy users). Associations between genotypes and body composition, by dual energy X-ray absorptiometry, were analyzed using univariate models. There was no main effect of individual genes on change in body composition, however, gene x exercise interactions were observed for A2B (Glu9/12) and B2 (Gln27Glu) on change in lean soft tissue (LST, p = 0.02); exercisers on the A2B (Glu9-) background gained LST compared to a loss among controls over 12 months (p < 0.05), with no significant intervention effect on the A2B (Glu9+) background. Similarly, there was a significant LST gain with exercise on the B2 (Glu27+) background compared to loss among controls and no intervention effect on the B2 (Glu27-) background. A non-significant association between total body fat (TBF) and B3 (Trp64Arg) persisted among sedentary controls only when intervention groups were separated (%TBF gain with B3 (Arg64+) carriage, p = 0.03); exercisers lost TBF regardless of genotype. In summary, effect modification by lifestyle was demonstrated on ADRA2B, B2, and B3 genetic backgrounds. Individuals with certain ADR genotypes may be more vulnerable to adverse changes in body composition with sedentary behavior, thus these candidate genes warrant further study.
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