ArticlePsychopharmacology2010
Alteration of intravenous nicotine self-administration by opioid receptor agonist and antagonists in rats.
Article in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Elucidating the reinforcing effects of nicotine: a tribute to Nadia Chaudhri.Psychopharmacology · 2023Review
- Nicotine and opioid co-dependence: Findings from bench research to clinical trials.Neuroscience and biobehavioral reviews · 2022Review
- Chronic Intermittent Sucrose Consumption Facilitates the Ability to Discriminate Opioid Receptor Blockade with Naltrexone in Rats.Nutrients · 2022Article
- Translational Research in Nicotine Addiction.Cold Spring Harbor perspectives in medicine · 2021Review
- Association Study of Opioid Receptor Delta-Type 1 (OPRD1) Gene Variants with Nicotine Dependence in an Iranian Population.Journal of molecular neuroscience : MN · 2021Article
- Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects.Psychopharmacology · 2021Article
- The Rise and Fall of Kappa-Opioid Receptors in Drug Abuse Research.Handbook of experimental pharmacology · 2020Review
- Nicotine Gateway Effects on Adolescent Substance Use.The western journal of emergency medicine · 2019Review
- Endogenous opioid system: a promising target for future smoking cessation medications.Psychopharmacology · 2017Review
- A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology.Translational psychiatry · 2016Article
- The opioid receptors as targets for drug abuse medication.British journal of pharmacology · 2015Review
- Nicotine and ethanol co-use in Long-Evans rats: Stimulatory effects of perinatal exposure to a fat-rich diet.Alcohol (Fayetteville, N.Y.) · 2015Article
- Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models.British journal of pharmacology · 2014Review
- Role of the kappa-opioid receptor system in stress-induced reinstatement of nicotine seeking in rats.Behavioural brain research · 2014Article
- Delta opioid receptors in brain function and diseases.Pharmacology & therapeutics · 2013Review
- Prenatal exposure to nicotine stimulates neurogenesis of orexigenic peptide-expressing neurons in hypothalamus and amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Development of novel pharmacotherapeutics for tobacco dependence: progress and future directions.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Review
- The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction.Psychopharmacology · 2012Review
- Influence of δ-opioid receptors in the behavioral effects of nicotine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Stress-induced activation of the dynorphin/κ-opioid receptor system in the amygdala potentiates nicotine conditioned place preference.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe role played by endogenous opioids in mediating the reinforcing properties of nicotine is unclear. As with preclinical studies, clinical trials with naloxone, a prototypic opioid receptor antagonist have yielded equivocal findings with regard to its efficacy in reducing cigarette smoking.
objectiveThe aim of the present study was to examine the effects of three opioids that exhibit relative selectivity at mu-, kappa- and delta-opioid receptors on nicotine self-administration in male hooded Lister rats.
methodsGraded doses (0.3, 1.0, and 3.0 mg/kg IP) of each opioid agonist or antagonist were tested in different groups of rats repeatedly over three consecutive nicotine intravenous nicotine-self administration (0.03 mg/kg/infusion) sessions. The same treatments were tested in parallel groups of rats trained to respond for food reinforcement.
resultsNaloxone was very effective in attenuating the levels of nicotine self-administered across all doses tested. The selective kappa-opioid receptor agonist U50,488, reduced nicotine self-administration in doses of 1 and 3 mg/kg, while the 0.3 mg/kg dose produced a small increase in nicotine intake. Finally, the specific delta-opioid receptor antagonist, naltrindole did not significantly modify nicotine self-administration behaviour. In contrast, all three opioids failed to modify behaviour maintained by food reinforcement.
conclusionsThese findings suggest endogenous opioids are crucial in mediating the reinforcing effects of nicotine and that the mu-opioid receptor subtype may represent a potential target for selectively reducing nicotine-taking behaviour as part of a pharmacological approach to develop smoking cessation aids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.