ArticleMolecular imaging and biology2011
[(Methyl)1-(11)c]-acetate metabolism in hepatocellular carcinoma.
Article in Molecular imaging and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- [Molecular imaging and biology · 2017Trial
- PET imaging of hepatocellular carcinoma with [EJNMMI research · 2025Article
- Image Synthesis in Nuclear Medicine Imaging with Deep Learning: A Review.Sensors (Basel, Switzerland) · 2024Review
- PET Imaging of Hepatocellular Carcinoma Using ZD2-(Journal of hepatocellular carcinoma · 2023Article
- Application of the woodchuck animal model for the treatment of hepatitis B virus-induced liver cancer.World journal of gastrointestinal oncology · 2021Review
- Liver background uptake of [American journal of nuclear medicine and molecular imaging · 2020Article
- PET imaging of hepatocellular carcinoma with anti-1-amino-3-[EJNMMI research · 2019Article
- Metabolic positron emission tomography imaging of cancer: Pairing lipid metabolism with glycolysis.World journal of radiology · 2016Article
- [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice.Molecular imaging and biology · 2016Article
- New approaches for precise response evaluation in hepatocellular carcinoma.World journal of gastroenterology · 2014Review
- Issues pertaining to PET imaging of liver cancer.Journal of fasting and health · 2014Article
- The effect of fasting on PET Imaging of Hepatocellular Carcinoma.Journal of cancer therapy · 2013Article
- Article
- Functional imaging techniques in hepatocellular carcinoma.European journal of nuclear medicine and molecular imaging · 2012Review
- SPECT and PET imaging of meningiomas.TheScientificWorldJournal · 2012Article
- Disturbances in the glutathione/ophthalmate redox buffer system in the woodchuck model of hepatitis virus-induced hepatocellular carcinoma.HPB surgery : a world journal of hepatic, pancreatic and biliary surgery · 2011Article
- Imaging for assessment of treatment response in hepatocellular carcinoma: Current update.The Indian journal of radiology & imagingArticle
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
purposeStudies have established the value of [(methyl)1-(11)C]-acetate ([(11)C]Act) combined with 2-deoxy-2[(18)F]fluoro-D-glucose (FDG) for detecting hepatocellular carcinoma (HCC) using positron emission tomography (PET). In this study, the metabolic fate of [(11)C]Act in HCC was characterized.
methodsExperiments with acetic acid [1-(14)C] sodium salt ([(14)C]Act) were carried out on WCH-17 cells and freshly derived rat hepatocytes. PET scans with [(11)C]Act were also carried out on woodchucks with HCC before injection of [(14)C]Act. The radioactivity levels in different metabolites were quantified with thin-layer chromatography.
resultsIn WCH-17 cells, the predominant metabolite was phosphatidylcholine (PC). Regions of HCCs with the highest [(11)C]Act uptake had higher radioactivity accumulation in lipid-soluble compounds than surrounding hepatic tissues. In those regions, PC and triacylglycerol (TG) accumulated more radioactivity than in surrounding hepatic tissues.
conclusionsHigh [(11)C]Act uptake in HCC is associated with increased de novo lipogenesis. PC and TG are the main metabolites into which the radioactive label from [(11)C]Act is incorporated in HCC.
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