ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2010
ApoE polymorphisms and diarrheal outcomes in Brazilian shanty town children.
Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- A systematic review and meta-analysis of the relationship between genes and reflexive attention.Frontiers in neuroscience · 2025Pooled it
- Effects of glutamine alone or in combination with zinc and vitamin A on growth, intestinal barrier function, stress and satiety-related hormones in Brazilian shantytown children.Clinics (Sao Paulo, Brazil) · 2014Trial
- Apolipoprotein E4 influences growth and cognitive responses to micronutrient supplementation in shantytown children from northeast Brazil.Clinics (Sao Paulo, Brazil) · 2012Trial
- Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments.PLoS genetics · 2026Article
- Evolutionary genetics of ageing.Nature reviews. Genetics · 2026Review
- Apolipoprotein E Polymorphism and Reproductive Patterns Among Postreproductive Women.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Divergent Biological Consequences of APOE Isoforms Across Industrialized and Non-Industrial Environments.bioRxiv : the preprint server for biology · 2026Article
- Human APOE4 Protects High-Fat and High-Sucrose Diet Fed Targeted Replacement Mice against Fatty Liver Disease Compared to APOE3.Aging and disease · 2024Article
- Characterizing the pathogenicity of genetic variants: the consequences of context.NPJ genomic medicine · 2024Article
- Article
- The Misguided Veneration of Averageness in Clinical Neuroscience: A Call to Value Diversity over Typicality.Brain sciences · 2023Review
- Current allele distribution of the human longevity gene APOE in Europe can mainly be explained by ancient admixture.Aging cell · 2023Article
- The mitochondrial BCKD complex interacts with hepatic apolipoprotein E in cultured cells in vitro and mouse livers in vivo.Cellular and molecular life sciences : CMLS · 2023Article
- DoFrontiers in neuroscience · 2023Article
- Evolutionary Approaches in Aging Research.Cold Spring Harbor perspectives in medicine · 2022Review
- Functional diversity of apolipoprotein E: from subcellular localization to mitochondrial function.Cellular and molecular life sciences : CMLS · 2022Review
- APOE genetics influence murine gut microbiome.Scientific reports · 2022Article
- Risk Factors for Severe COVID-19 and Hepatitis C Infections: The Dual Role of Apolipoprotein E4.Frontiers in immunology · 2022Article
- Article
- Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men.Journal of the International Neuropsychological Society : JINS · 2021Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
A series of studies have shown that the heavy burdens of diarrheal diseases in the first 2 formative years of life in children living in urban shanty towns have negative effects on physical and cognitive development lasting into later childhood. We have shown that APOE4 is relatively common in shanty town children living in Brazil (13.4%) and suggest that APOE4 has a protective role in cognitive development as well as weight-for-height in children with heavy burdens of diarrhea in early childhood (64/123; 52%), despite being a marker for cognitive decline with Alzheimer's and cardiovascular diseases later in life. APOE2 frequency was higher among children with heaviest diarrhea burdens during the first 2 years of life, as detected by PCR using the restriction fragment length polymorphism method, raising the possibility that ApoE-cholesterol balance might be critical for growth and cognitive development under the stress of heavy diarrhea burdens and when an enriched fat diet is insufficient. These findings provide a potential explanation for the survival advantage in evolution of genes, which might raise cholesterol levels during heavy stress of diarrhea burdens and malnutrition early in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.