ArticleOrganic & biomolecular chemistry2010
Reagent based DOS: a "Click, Click, Cyclize" strategy to probe chemical space.
Article in Organic & biomolecular chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Untargeted Diversity-Oriented Synthesis for the Discovery of New Antitumor Agents: An Integrated Approach of Inverse Virtual Screening, Bioinformatics, and Omics for Target Deconvolution.Journal of medicinal chemistry · 2025Article
- Synthesis of Medium-Sized Heterocycles by Transition-Metal-Catalyzed Intramolecular Cyclization.Molecules (Basel, Switzerland) · 2020Review
- Synthesis of cyclic 1,3-diols as scaffolds for spatially directed libraries.Organic & biomolecular chemistry · 2016Article
- Modular, One-Pot, Sequential Aziridine Ring Opening-S(N)Ar Strategy to 7-, 10-, and 11-Membered Benzo-Fused Sultams.The Journal of organic chemistry · 2015Article
- A summary of seven- and eight-membered ring sultam syntheses via three Michael addition reactions.Molecular diversity · 2015Article
- 3,2-Hydroxypyridinone (3,2-HOPO) vinyl sulfonamide and acrylamide linkers: Aza-Michael addition reactions and the preparation of poly-HOPO chelators.Tetrahedron letters · 2013Article
- Multicapillary Flow Reactor: Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS).Journal of flow chemistry · 2012Article
- Facile (triazolyl)methylation of MACOS-derived benzofused sultams utilizing ROMP-derived OTP reagents.ACS combinatorial science · 2012Article
- Exploring chemical diversity via a modular reaction pairing strategy.Beilstein journal of organic chemistry · 2012Article
- Synthesis of an Isoindoline-Annulated, Tricyclic Sultam Library via Microwave-Assisted, Continuous-Flow Organic Synthesis (MACOS).Synthesis · 2012Article
- Synthesis of amino-benzothiaoxazepine-1,1-dioxides utilizing a microwave-assisted, S(N)Ar protocol.ACS combinatorial science · 2011Article
- Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol.Chemical communications (Cambridge, England) · 2011Article
- Synthesis of a stereochemically diverse library of medium-sized lactams and sultams via S(N)Ar cycloetherification.ACS combinatorial science · 2011Article
- Automated synthesis of a 184-member library of thiadiazepan-1,1-dioxide-4-ones.ACS combinatorial science · 2011Article
- Increased diversity of libraries from libraries: chemoinformatic analysis of bis-diazacyclic libraries.Chemical biology & drug design · 2011Article
- Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.Nature communications · 2010Article
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Authors and funding
3 authors.
Funding
Abstract
The synthesis of small organic molecules as probes for discovering new therapeutic agents has been an important aspect of chemical-biology. Herein we report a reagent-based, diversity-oriented synthetic (DOS) strategy to probe chemical and biological space via a "Click, Click, Cyclize" protocol. In this DOS approach, three sulfonamide linchpins underwent cyclization protocols with a variety of reagents to yield a collection of structurally diverse S-heterocycles. In silico analysis is utilized to evaluate the diversity of the compound collection against chemical space (PC analysis), shape space (PMI) and polar surface area (PSA) calculations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.