ArticleExpert review of endocrinology & metabolism2010
Insulin secretion and insulin-producing tumors.
Article in Expert review of endocrinology & metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Surgical Management of Sporadic Pancreatic Insulinomas in a Resource-Limited Setting: A Report of Two Cases.Case reports in surgery · 2026Article
- Diagnosis and management of benign secreting pancreatic insulinoma: What's new? 4 case report.Rare tumors · 2025Article
- Genotype-histotype-phenotype correlations in hyperinsulinemic hypoglycemia.Histology and histopathology · 2024Review
- Identifying target ion channel-related genes to construct a diagnosis model for insulinoma.Frontiers in genetics · 2023Article
- Characterization of the Secretome, Transcriptome, and Proteome of Human β Cell Line EndoC-βH1.Molecular & cellular proteomics : MCP · 2022Article
- Identification of genetic variants for blood insulin level in sex-stratified Korean population and evaluation of the causal relationship between blood insulin level and polycystic ovary syndrome.Genes & genomics · 2021Article
- Using the Secretion Ratios of Insulin and C-peptide During the 2-h Oral Glucose Tolerance Test to Diagnose Insulinoma.Digestive diseases and sciences · 2021Article
- Article
- The functioning side of the pancreas: a review on insulinomas.Journal of endocrinological investigation · 2020Review
- Superior Diagnostic Performance of the GLP-1 Receptor Agonist [LysMolecular imaging and biology · 2020Article
- Recent advances in the diagnosis and management of pancreatic neuroendocrine tumours.Frontline gastroenterology · 2019Review
- Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management.Endocrine connections · 2017Article
- Pancreatic insulinomas: Laparoscopic management.World journal of gastrointestinal endoscopy · 2015Review
- Laparoscope resection of retroperitoneal ectopic insulinoma: a rare case.World journal of gastroenterology · 2015Article
- Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast.Cell research · 2012Article
- ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: functional pancreatic endocrine tumor syndromes.Neuroendocrinology · 2012Article
- Iatrogenic occult infection causing hypoglycemia in a teenage female.Annals of Saudi medicineArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Insulinomas are rare neuroendocrine tumors of pancreatic islet cells that retain the ability to produce and secrete insulin. In contrast to normally differentiated β-cells, insulinoma cells continue to secrete insulin and proinsulin at low blood glucose. This deregulated insulin secretion manifests clinically as fasting hypoglycemia. The molecular pathways that characterize normal insulin secretion and β-cell growth are reviewed and contrasted to the biology of insulinomas. The second half of this review summarizes the clinical approach to the disorder. The diagnosis of insulinoma is established by demonstrating inappropriately high insulin levels with coincident hypoglycemia at the time of a supervised fast. Localization of insulinomas is challenging owing to their small size but should be attempted to maximize the chance for successful surgical resection and avoid risks associated with reoperation. In the majority of cases, successful surgical resection leads to lifelong cure.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.