ArticleNature nanotechnology2010
A double-stranded DNA rotaxane.
Article in Nature nanotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 148 citations in OpenAlex.
- Visualizing poloidal orientation in DNA minicircles.Biophysical journal · 2026Article
- Stable and programmable formation of DNA nanostructures via inter-strand crosslinking by assembly-triggered oxanine and amine linkage.Nucleic acids research · 2026Article
- Programming DNA machines to move.Nature reviews. Chemistry · 2026Review
- Dynamic Catalysis Guided by Nucleic Acid Networks and DNA Nanostructures.Bioconjugate chemistry · 2023Review
- Chemically modified nucleic acids and DNA intercalators as tools for nanoparticle assembly.Chemical Society reviews · 2021Review
- Chiral Systems Made from DNA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Aptamer-Functionalized Hybrid Nanostructures for Sensing, Drug Delivery, Catalysis and Mechanical Applications.International journal of molecular sciences · 2021Review
- Mechanical Flexibility of DNA: A Quintessential Tool for DNA Nanotechnology.Sensors (Basel, Switzerland) · 2020Review
- Interlocked DNA Nanojoints for Reversible Thermal Sensing.Angewandte Chemie (International ed. in English) · 2020Article
- Dynamic DNA Assemblies in Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides.Journal of the American Chemical Society · 2020Article
- Design, assembly, characterization, and operation of double-stranded interlocked DNA nanostructures.Nature protocols · 2019Article
- Growing prospects of DNA nanomaterials in novel biomedical applications.RSC advances · 2019Review
- Programming molecular topologies from single-stranded nucleic acids.Nature communications · 2018Article
- Structural optimization of pseudorotaxane-forming oligonucleotides for efficient and stable complex formation.Nucleic acids research · 2018Article
- A bio-hybrid DNA rotor-stator nanoengine that moves along predefined tracks.Nature nanotechnology · 2018Article
- Complex lasso: new entangled motifs in proteins.Scientific reports · 2016Article
- Creating complex molecular topologies by configuring DNA four-way junctions.Nature chemistry · 2016Article
- DNA Origami Rotaxanes: Tailored Synthesis and Controlled Structure Switching.Angewandte Chemie (International ed. in English) · 2016Article
- Long-range movement of large mechanically interlocked DNA nanostructures.Nature communications · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanically interlocked molecules such as rotaxanes and catenanes have potential as components of molecular machinery. Rotaxanes consist of a dumb-bell-shaped molecule encircled by a macrocycle that can move unhindered along the axle, trapped by bulky stoppers. Previously, rotaxanes have been made from a variety of molecules, but not from DNA. Here, we report the design, assembly and characterization of rotaxanes in which both the dumb-bell-shaped molecule and the macrocycle are made of double-stranded DNA, and in which the axle of the dumb-bell is threaded through the macrocycle by base pairing. The assembly involves the formation of pseudorotaxanes, in which the macrocycle and the axle are locked together by hybridization. Ligation of stopper modules to the axle leads to the characteristic dumb-bell topology. When an oligonucleotide is added to release the macrocycle from the axle, the pseudorotaxanes are either converted to mechanically stable rotaxanes, or they disassemble by means of a slippage mechanism to yield a dumb-bell and a free macrocycle. Our DNA rotaxanes allow the fields of mechanically interlocked molecules and DNA nanotechnology to be combined, thus opening new possibilities for research into molecular machines and synthetic biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.