ArticleCritical care medicine2010
Perivascular fluid cuffs decrease lung compliance by increasing tissue resistance.
Article in Critical care medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
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- Endothelial hyperpermeability in severe pulmonary arterial hypertension: role of store-operated calcium entry.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.PLoS genetics · 2015Article
- The cardiac protein αT-catenin contributes to chemical-induced asthma.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- The heterogeneity of regional specific ventilation is unchanged following heavy exercise in athletes.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Pseudomonas aeruginosa exotoxin Y is a promiscuous cyclase that increases endothelial tau phosphorylation and permeability.The Journal of biological chemistry · 2012Article
- Studies on the cell biology of interendothelial cell gaps.American journal of physiology. Lung cellular and molecular physiology · 2012Review
- Analysis of pulmonary vascular injury and repair during Pseudomonas aeruginosa infection-induced pneumonia and acute respiratory distress syndrome.Pulmonary circulationArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveLung inflammation causes perivascular fluid cuffs to form around extra-alveolar blood vessels; however, the physiologic consequences of such cuffs remain poorly understood. Herein, we tested the hypothesis that perivascular fluid cuffs, without concomitant alveolar edema, are sufficient to decrease lung compliance.
designProspective, randomized, controlled study.
settingResearch laboratory. SUBJECTS: One hundred twenty male CD40 rats.
interventionsTo test this hypothesis, the plant alkaloid thapsigargin was used to activate store-operated calcium entry and increase cytosolic calcium in endothelium. Thapsigargin was infused into a central venous catheter of intact, sedated, and mechanically ventilated rats. MEASUREMENTS: Static and dynamic lung mechanics and hemodynamics were measured continuously. MAIN
resultsThapsigargin produced perivascular fluid cuffs along extra-alveolar vessels but did not cause alveolar flooding or blood gas abnormalities. Lung compliance dose-dependently decreased after thapsigargin infusion, attributable to an increase in tissue resistance that was attributed to increased tissue damping and tissue elastance. Airway resistance was not changed. Neither central venous pressure nor left ventricular end diastolic pressure was altered by thapsigargin. Heart rate did not change, although thapsigargin decreased left ventricular systolic function sufficient to reduce cardiac output by 50%. Infusion of the type 4 phosphodiesterase inhibitor, rolipram, prevented thapsigargin from inducing perivascular cuffs and decreasing lung compliance. Rolipram also normalized pressure over time and corrected the deficit in cardiac output.
conclusionsOur findings resolve for the first time that perivascular cuff formation negatively impacts mechanical coupling between the bronchovascular bundle and the lung parenchyma, decreasing lung compliance without impacting central venous pressure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.