ArticleCirculation. Cardiovascular genetics2010
Candidate gene association resource (CARe): design, methods, and proof of concept.
Article in Circulation. Cardiovascular genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 23 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
117 citing papers in PubMed, 23 syntheses or guidelines pooled it.
- Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans.Human molecular genetics · 2016Pooled it
- Common variants in DRD2 are associated with sleep duration: the CARe consortium.Human molecular genetics · 2016Pooled it
- Increased Plasma PCSK9 Levels Are Associated with Reduced Endotoxin Clearance and the Development of Acute Organ Failures during Sepsis.Journal of innate immunity · 2016Pooled it
- Fetuin-A and risk of coronary heart disease: A Mendelian randomization analysis and a pooled analysis of AHSG genetic variants in 7 prospective studies.Atherosclerosis · 2015Pooled it
- A common SCN5A variant is associated with PR interval and atrial fibrillation among African Americans.Journal of cardiovascular electrophysiology · 2014Pooled it
- Meta-analysis of loci associated with age at natural menopause in African-American women.Human molecular genetics · 2014Pooled it
- APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema.The European respiratory journal · 2014Pooled it
- Replication and fine mapping of asthma-associated loci in individuals of African ancestry.Human genetics · 2013Pooled it
- Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.Human molecular genetics · 2013Pooled it
- Genetics of coronary artery calcification among African Americans, a meta-analysis.BMC medical genetics · 2013Pooled it
- Loci influencing blood pressure identified using a cardiovascular gene-centric array.Human molecular genetics · 2013Pooled it
- Genetic analysis of a population heavy drinking phenotype identifies risk variants in whites.Journal of clinical psychopharmacology · 2013Pooled it
- Genetic associations with valvular calcification and aortic stenosis.The New England journal of medicine · 2013Pooled it
- Contribution of common PCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population.PloS one · 2013Pooled it
- Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium.Atherosclerosis · 2012Pooled it
- Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.American journal of human genetics · 2012Pooled it
- Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.PloS one · 2012Pooled it
- Post-genomic update on a classical candidate gene for coronary artery disease: ESR1.Circulation. Cardiovascular genetics · 2011Pooled it
- Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.Human molecular genetics · 2011Pooled it
- Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium.Human molecular genetics · 2011Pooled it
57 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
38 authors.
Funding
Abstract
backgroundThe National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe), a planned cross-cohort analysis of genetic variation in cardiovascular, pulmonary, hematologic, and sleep-related traits, comprises >40,000 participants representing 4 ethnic groups in 9 community-based cohorts. The goals of CARe include the discovery of new variants associated with traits using a candidate gene approach and the discovery of new variants using the genome-wide association mapping approach specifically in African Americans. METHODS AND
resultsCARe has assembled DNA samples for >40,000 individuals self-identified as European American, African American, Hispanic, or Chinese American, with accompanying data on hundreds of phenotypes that have been standardized and deposited in the CARe Phenotype Database. All participants were genotyped for 7 single-nucleotide polymorphisms (SNPs) selected based on prior association evidence. We performed association analyses relating each of these SNPs to lipid traits, stratified by sex and ethnicity, and adjusted for age and age squared. In at least 2 of the ethnic groups, SNPs near CETP, LIPC, and LPL strongly replicated for association with high-density lipoprotein cholesterol concentrations, PCSK9 with low-density lipoprotein cholesterol levels, and LPL and APOA5 with serum triglycerides. Notably, some SNPs showed varying effect sizes and significance of association in different ethnic groups.
conclusionsThe CARe Pilot Study validates the operational framework for phenotype collection, SNP genotyping, and analytic pipeline of the CARe project and validates the planned candidate gene study of approximately 2000 biological candidate loci in all participants and genome-wide association study in approximately 8000 African American participants. CARe will serve as a valuable resource for the scientific community.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.