ArticleJournal of dental research2010
Azithromycin decreases crevicular fluid volume and mediator content.
Article in Journal of dental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The Immunomodulatory Effects of Macrolides-A Systematic Review of the Underlying Mechanisms.Frontiers in immunology · 2018Pooled it
- Comparison of Azithromycin and Amoxicillin Before Dental Implant Placement: An Exploratory Study of Bioavailability and Resolution of Postoperative Inflammation.Journal of periodontology · 2015Trial
- Effect of gingivitis on azithromycin concentrations in gingival crevicular fluid.Journal of periodontology · 2012Trial
- Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects.Journal of clinical periodontology · 2012Trial
- Azithromycin buccal patch in treatment of chronic periodontitis.Indian journal of pharmacologyTrial
- Immunomodulatory Effects of Macrolides Considering Evidence from Human and Veterinary Medicine.Microorganisms · 2022Review
- Optimisation of treatments for oralBMJ open · 2022Article
- Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed periodontium.International journal of oral science · 2021Article
- Inhibition of neutrophil inflammatory mediator expression by azithromycin.Clinical oral investigations · 2020Article
- GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis.Biomaterials · 2020Article
- Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa.ACS infectious diseases · 2019Article
- Nonsurgical therapy of chronic periodontitis with adjunctive systemic azithromycin or amoxicillin/metronidazole.Clinical oral investigations · 2016Article
- Azithromycin suppresses P. gingivalis LPS-induced pro-inflammatory cytokine and chemokine production by human gingival fibroblasts in vitro.Clinical oral investigations · 2015Article
- Resolution of localized chronic periodontitis associated with longstanding calculus deposits.Case reports in dentistry · 2014Article
- Antibacterial and immunomodulatory properties of azithromycin treatment implications for periodontitis.Inflammopharmacology · 2013Review
- Lessons learned and unlearned in periodontal microbiology.Periodontology 2000 · 2013Review
- Azithromycin kills invasive Aggregatibacter actinomycetemcomitans in gingival epithelial cells.Antimicrobial agents and chemotherapy · 2013Article
- Azithromycin concentrations in blood and gingival crevicular fluid after systemic administration.Journal of periodontology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Azithromycin enhances the response to root planing and produces anti-inflammatory effects in treating chronic lung disease. This led us to hypothesize that azithromycin inhibits inflammatory mediator production in gingiva, leading to decreased gingival crevicular fluid (GCF) volume. To test this hypothesis, ten periodontally healthy volunteers received azithromycin every 24 hours for 48 hours. GCF samples were collected from 12 maxillary interproximal sites prior to azithromycin (baseline) and 2, 4, 7, and 14 days later. Samples were assayed for IL-1beta, IL-8, TNF-alpha, VEGF, IL-6, and IL-10. With azithromycin treatment, GCF volume decreased significantly on days 2 through 7 (P < 0.05), but increased toward baseline levels on day 14. This was accompanied by a transient decrease in the content of IL-1beta, IL-8, TNF-alpha, and VEGF (P < 0.05). IL-6 and IL-10 were not detected. Since plaque was absent throughout the study, the findings suggest that azithromycin produces anti-inflammatory effects in gingiva.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.