ArticleProceedings of the National Academy of Sciences of the United States of America2010
Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed.
- Discriminating single-amino acid differences and post-translational modifications in negatively charged peptides with α-hemolysin nanopores.Journal of nanobiotechnology · 2026Article
- Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026Review
- Hetero-Oligomeric Protein Pores for Single-Molecule Sensing.The Journal of membrane biology · 2025Review
- Antibacterial and Inhibitory Activity of Nora and Mepa Efflux Pumps of Estragole Complexed to β-Cyclodextrin (ES/β-CD) In Vitro AgainstPharmaceutics · 2024Article
- Single-molecule profiling of per- and polyfluoroalkyl substances by cyclodextrin mediated host-guest interactions within a biological nanopore.Science advances · 2024Article
- Cyclodextrins: Only Pharmaceutical Excipients or Full-Fledged Drug Candidates?Pharmaceutics · 2022Review
- Weak complexation of 5-fluorouracil with β-cyclodextrin, carbonate, and dianhydride crosslinked β-cyclodextrin:Research in pharmaceutical sciences · 2022Article
- Functionalised nanopores: chemical and biological modifications.Chemical science · 2022Review
- Epitranscriptomics of cardiovascular diseases (Review).International journal of molecular medicine · 2022Review
- Review
- Biological Nanopores: Engineering on Demand.Life (Basel, Switzerland) · 2021Review
- Cyclodextrins Exert a Ligand-like Current Inhibitory Effect on the KFrontiers in molecular biosciences · 2021Article
- New Twists in Detecting mRNA Modification Dynamics.Trends in biotechnology · 2021Review
- Ion Mobility-Mass Spectrometry Reveals That α-Hemolysin fromAnalytical chemistry · 2019Article
- Salt-Mediated Nanopore Detection of ADAM-17.ACS applied bio materials · 2019Article
- Polynucleotide transport through lipid membrane in the presence of starburst cyclodextrin-based poly(ethylene glycol)s.The European physical journal. E, Soft matter · 2018Article
- A monodisperse transmembrane α-helical peptide barrel.Nature chemistry · 2017Article
- Why does β-cyclodextrin prefer to bind nucleotides with an adenine base rather than other 2'-deoxyribonucleoside 5'-monophosphates?Journal of molecular modeling · 2017Article
- Engineered transmembrane pores.Current opinion in chemical biology · 2016Review
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Engineered protein pores have several potential applications in biotechnology: as sensor elements in stochastic detection and ultrarapid DNA sequencing, as nanoreactors to observe single-molecule chemistry, and in the construction of nano- and micro-devices. One important class of pores contains molecular adapters, which provide internal binding sites for small molecules. Mutants of the alpha-hemolysin (alphaHL) pore that bind the adapter beta-cyclodextrin (betaCD) approximately 10(4) times more tightly than the wild type have been obtained. We now use single-channel electrical recording, protein engineering including unnatural amino acid mutagenesis, and high-resolution x-ray crystallography to provide definitive structural information on these engineered protein nanopores in unparalleled detail.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.