ArticleThe Plant cell2010
Cell Number Regulator1 affects plant and organ size in maize: implications for crop yield enhancement and heterosis.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.
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Who cites it
129 citing papers in PubMed, 280 citations in OpenAlex.
- Histone deacetylase complex 1 modulates sepal length through the ethylene-ROS module.Plant cell reports · 2026Article
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- Dynamics of Gene and Allelic Expression During Modern Hybrid Maize Breeding.Plant biotechnology journal · 2026Article
- Establishment of a Genetic Transformation System forPlants (Basel, Switzerland) · 2026Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2026Article
- The CELL NUMBER REGULATOR SlFWL5 protein regulates aerial vegetative growth in tomato, by promoting cell expansion.Journal of experimental botany · 2026Article
- Large DNA and protein language models enhance discovery of deleterious mutations in maize.Genome biology · 2025Article
- Review
- Functional insights into JrWOX5: a WOX transcription factor regulating adventitious rooting and plant architecture in walnut.Plant cell reports · 2025Article
- Hybrids reveal accessible chromatinbioRxiv : the preprint server for biology · 2025Article
- CRISPR-Cas9: Unraveling Genetic Secrets to Enhance Floral and Fruit Traits in Tomato.Molecular biotechnology · 2025Review
- Article
- Research Progress onBiology · 2025Review
- Single-cell RNA sequencing reveals a key regulator ZmEREB14 affecting shoot apex development and yield formation in maize.Plant biotechnology journal · 2025Article
- Tomato FW2.2/CNR might regulate fruit size via plasmodesmata callose deposition.Plant physiology · 2024Article
- The CELL NUMBER REGULATOR FW2.2 protein regulates cell-to-cell communication in tomato by modulating callose deposition at plasmodesmata.Plant physiology · 2024Article
- A dynamic regulome of shoot-apical-meristem-related homeobox transcription factors modulates plant architecture in maize.Genome biology · 2024Article
- Cytological and Transcriptome Analyses Provide Insights into Persimmon Fruit Size Formation (International journal of molecular sciences · 2024Article
- AsHSP26.2, a creeping bentgrass chloroplast small heat shock protein positively regulates plant development.Plant cell reports · 2024Article
- Genetic mapping reveals a candidate geneFrontiers in plant science · 2024Article
69 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genes involved in cell number regulation may affect plant growth and organ size and, ultimately, crop yield. The tomato (genus Solanum) fruit weight gene fw2.2, for instance, governs a quantitative trait locus that accounts for 30% of fruit size variation, with increased fruit size chiefly due to increased carpel ovary cell number. To expand investigation of how related genes may impact other crop plant or organ sizes, we identified the maize (Zea mays) gene family of putative fw2.2 orthologs, naming them Cell Number Regulator (CNR) genes. This family represents an ancient eukaryotic family of Cys-rich proteins containing the PLAC8 or DUF614 conserved motif. We focused on native expression and transgene analysis of the two maize members closest to Le-fw2.2, namely, CNR1 and CNR2. We show that CNR1 reduced overall plant size when ectopically overexpressed and that plant and organ size increased when its expression was cosuppressed or silenced. Leaf epidermal cell counts showed that the increased or decreased transgenic plant and organ size was due to changes in cell number, not cell size. CNR2 expression was found to be negatively correlated with tissue growth activity and hybrid seedling vigor. The effects of CNR1 on plant size and cell number are reminiscent of heterosis, which also increases plant size primarily through increased cell number. Regardless of whether CNRs and other cell number-influencing genes directly contribute to, or merely mimic, heterosis, they may aid generation of more vigorous and productive crop plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.