ArticleJournal of leukocyte biology2010
The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B.
Article in Journal of leukocyte biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 104 citations in OpenAlex.
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- Pathology of spontaneous and immunotherapy-induced tumor regression in a murine model of melanoma.Pigment cell & melanoma research · 2019Article
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- Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1-Like Ocular Disease in Mice.The American journal of pathology · 2018Article
- Induction of NLRP3 Inflammasome Activation by Heme in Human Endothelial Cells.Oxidative medicine and cellular longevity · 2018Article
- Endometrial apoptosis and neutrophil infiltration during menstruation exhibits spatial and temporal dynamics that are recapitulated in a mouse model.Scientific reports · 2017Article
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- A late-lineage murine neutrophil precursor population exhibits dynamic changes during demand-adapted granulopoiesis.Scientific reports · 2017Article
- Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner.PloS one · 2017Article
- Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity.JCI insight · 2016Article
- Evidence for a dynamic role for mononuclear phagocytes during endometrial repair and remodelling.Scientific reports · 2016Article
- Bone marrow-derived macrophages distinct from tissue-resident macrophages play a pivotal role in Concanavalin A-induced murine liver injury via CCR9 axis.Scientific reports · 2016Article
- IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation.European journal of immunology · 2016Article
Corrections and comments
- Erratum issuedErratum.2011
- Erratum issued
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
This study aimed to identify the inflammation-associated 7/4-antigen, which is highly expressed on neutrophils, inflammatory monocytes, some activated macrophages, as well as on bone marrow myeloid-restricted progenitors. The high expression on inflammatory cells is suggestive of a role in inflammation and makes the 7/4-antigen a potential target for the manipulation of inflammatory cells. Consistent with this, the 7/4-antibody mediates specific depletion of 7/4-expressing neutrophils and monocytes. We have identified the 7/4-antigen as a 25- to 30-kDa GPI-anchored glycoprotein synonymous with the Ly-6B.2 alloantigen. We characterized the expression of Ly-6B during the inflammatory reaction induced by zymosan. During the later stages of an experimental, acute, self-resolving inflammatory response, we found that Ly-6B is differentially expressed on macrophages. Ly-6B-expressing macrophages also express more MHCII, CIITA, CCR2, Ly-6C, and CD62L than the Ly-6B-negative macrophages, which in turn, express more of the resident tissue macrophage marker SIGN-R1 and higher CD11b and F4/80. Ly-6B-expressing macrophages incorporate more BrdU than their Ly-6B-negative contemporaries when fed during the resolution phase of the acute inflammatory response. Thus, Ly-6B expression on mature macrophages defines a subset of recently generated inflammatory macrophages that retain monocytic markers and is hence a surrogate marker of macrophage turnover in inflammatory lesions. The definition of the 7/4:Ly-6B antigen will allow further characterization and specific modulation of Ly-6B-expressing cells in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.