ArticleApplied and environmental microbiology2010
Antibiotic resistance characteristics of environmental bacteria from an oxytetracycline production wastewater treatment plant and the receiving river.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
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Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 294 citations in OpenAlex.
- Structure of Bacterial Community with Resistance to Antibiotics in Aquatic Environments. A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Cold stress reshapes gut microbiota and antibiotic resistance in ornamental fish (Cyprinus carpio).Antonie van Leeuwenhoek · 2026Article
- Treatment of antibiotic-manufacturing wastewater enriches for Aeromonas veronii, a zoonotic antibiotic-resistant emerging pathogen.The ISME journal · 2025Article
- A Review of the Dissemination of Antibiotic Resistance through Wastewater Treatment Plants: Current Situation in Sri Lanka and Future Perspectives.Life (Basel, Switzerland) · 2024Review
- Non-antibiotic pharmaceuticals are toxic against Escherichia coli with no evolution of cross-resistance to antibiotics.npj antimicrobials and resistance · 2024Article
- Mitigating Antibiotic Resistance Emissions in the Pharmaceutical Industry: Global Governance and Available Techniques.China CDC weekly · 2023Review
- Subsidized veterinary extension services may reduce antimicrobial resistance in aquaculture.Scientific reports · 2023Article
- Unveiling antimicrobial resistance in Chilean fertilized soils: a One Health perspective on environmental AMR surveillance.Frontiers in microbiology · 2023Article
- Minimizing Risks of Antimicrobial Resistance Development in the Environment from a Public One Health Perspective.China CDC weekly · 2022Article
- Low levels of tetracyclines select for a mutation that prevents the evolution of high-level resistance to tigecycline.PLoS biology · 2022Article
- Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches.World journal of microbiology & biotechnology · 2022Review
- Applications of Heterogeneous Photocatalysis to the Degradation of Oxytetracycline in Water: A Review.Molecules (Basel, Switzerland) · 2022Review
- Impact of oxytetracycline exposure on the digestive system microbiota of Daphnia magna.PloS one · 2022Article
- Factors associated with Salmonella enterica and Escherichia coli during downtime in commercial broiler chicken barns in Ontario.Poultry science · 2021Article
- A Model to Investigate the Impact of Farm Practice on Antimicrobial Resistance in UK Dairy Farms.Bulletin of mathematical biology · 2021Article
- A One Health Comparative Assessment of Antimicrobial Resistance in Generic and Extended-Spectrum Cephalosporin-ResistantMicroorganisms · 2020Article
- The Contribution of Wastewater to the Transmission of Antimicrobial Resistance in the Environment: Implications of Mass Gathering Settings.Tropical medicine and infectious disease · 2020Review
- Distribution of Antibiotic-ResistantFrontiers in microbiology · 2020Article
- Antibiotic resistance genes in the Actinobacteria phylum.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- Whole Genome Sequencing of Extended-Spectrum Beta-Lactamase (ESBL)-ProducingFrontiers in microbiology · 2019Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We characterized the bacterial populations in surface water receiving effluent from an oxytetracycline (OTC) production plant. Additional sampling sites included the receiving river water 5 km upstream and 20 km downstream from the discharge point. High levels of OTC were found in the wastewater (WW), and the antibiotic was still detectable in river water downstream (RWD), with undetectable levels in river water upstream (RWU). A total of 341 bacterial strains were isolated using nonselective media, with the majority being identified as Gammaproteobacteria. The MICs were determined for 10 antibiotics representing seven different classes of antibiotics, and the corresponding values were significantly higher for the WW and RWD isolates than for the RWU isolates. Almost all bacteria (97%) from the WW and RWD samples demonstrated multidrug-resistant (MDR) phenotypes, while in RWU samples, these were less frequent (28%). The WW and RWD isolates were analyzed for the presence of 23 tetracycline (tet) resistance genes. The majority of isolates (94.2% and 95.4% in WW and RWD, respectively) harbored the corresponding genes, with tet(A) being the most common (67.0%), followed by tet(W), tet(C), tet(J), tet(L), tet(D), tet(Y), and tet(K) (in the range between 21.0% and 40.6%). Class I integrons were detected in the majority of WW and RWD isolates (97.4% and 86.2%, respectively) but were not associated with the tet genes. We hypothesize that the strong selective pressure imposed by a high concentration of OTC contributes to the wide dissemination of tetracycline resistance genes and other antibiotic resistance genes, possibly through mobile genetic elements.
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