ArticleEukaryotic cell2010
Isocitrate dehydrogenase is important for nitrosative stress resistance in Cryptococcus neoformans, but oxidative stress resistance is not dependent on glucose-6-phosphate dehydrogenase.
Article in Eukaryotic cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Effect of cadmium toxicity on growth, physiochemical parameters and antioxidant system of castor seedlings.Heliyon · 2024Article
- Kinetic and Regulatory Properties ofInternational journal of molecular sciences · 2023Article
- Gluconate Kinase Is Required for Gluconate Assimilation and Sporulation in Cryptococcus neoformans.Microbiology spectrum · 2022Article
- What Are the Best Parents for Hybrid Progeny? An Investigation into the Human Pathogenic FungusJournal of fungi (Basel, Switzerland) · 2021Article
- Stress Induces Release of Extracellular Vesicles byJournal of immunology research · 2021Article
- Basic principles of the virulence ofVirulence · 2019Review
- Label-Free Proteomic Analysis of Flavohemoglobin Deleted Strain of Saccharomyces cerevisiae.International journal of proteomics · 2016Article
- Identification of differentially expressed proteins from Leishmania amazonensis associated with the loss of virulence of the parasites.PLoS neglected tropical diseases · 2014Article
- Global transcriptome profile of Cryptococcus neoformans during exposure to hydrogen peroxide induced oxidative stress.PloS one · 2013Article
- Proteomic profiling of Rhizobium tropici PRF 81: identification of conserved and specific responses to heat stress.BMC microbiology · 2012Article
- The CovS/CovR acid response regulator is required for intracellular survival of group B Streptococcus in macrophages.Infection and immunity · 2012Article
- A proteomic analysis of liver after ethanol binge in chronically ethanol treated rats.Proteome science · 2012Article
- Article
- One-step metabolomics: carbohydrates, organic and amino acids quantified in a single procedure.Journal of visualized experiments : JoVE · 2010Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The opportunistic intracellular fungal pathogen Cryptococcus neoformans depends on many antioxidant and denitrosylating proteins and pathways for virulence in the immunocompromised host. These include the glutathione and thioredoxin pathways, thiol peroxidase, cytochrome c peroxidase, and flavohemoglobin denitrosylase. All of these ultimately depend on NADPH for either catalytic activity or maintenance of a reduced, functional form. The need for NADPH during oxidative stress is well established in many systems, but a role in resistance to nitrosative stress has not been as well characterized. In this study we investigated the roles of two sources of NADPH, glucose-6-phosphate dehydrogenase (Zwf1) and NADP(+)-dependent isocitrate dehydrogenase (Idp1), in production of NADPH and resistance to oxidative and nitrosative stress. Deletion of ZWF1 in C. neoformans did not result in an oxidative stress sensitivity phenotype or changes in the amount of NADPH produced during oxidative stress compared to those for the wild type. Deletion of IDP1 resulted in greater sensitivity to nitrosative stress than to oxidative stress. The amount of NADPH increased 2-fold over that in the wild type during nitrosative stress, and yet the idp1Delta strain accumulated more mitochondrial damage than the wild type during nitrosative stress. This is the first report of the importance of Idp1 and NADPH for nitrosative stress resistance.
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