ArticleImmunobiology
Ex vivo enzymatic treatment of aged CD4 T cells restores antigen-driven CD69 expression and proliferation in mice.
Article in Immunobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Increased mammalian target of rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Ex vivo enzymatic treatment of aged CD4 T cells restores cognate T cell helper function and enhances antibody production in mice.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Age-related changes in CD8 T cell homeostasis and immunity to infection.Seminars in immunology · 2012Review
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Declines in immune function have been associated with declines in the function of naïve CD4 T cells. In vitro studies of naïve CD4 T cells in TCR-specific transgenic AND mice have shown age-related defects in immunosynapse formation, activation, proliferation and cytokine production. Previous work has also documented age-related alteration in the glycosylation of surface proteins involved in TCR signaling, and shown that enzymatic treatments to remove specific surface glycoproteins can restore in vitro function in CD4 cells from aged mice. Here an adoptive transfer system shows that a large percentage of naïve CD4 T cells from old mice fail to express CD69 and expand in antigen-primed mice, but these declines in CD69 and expansion can be restored by ex vivo pretreatment of the T cells with the bacterial enzyme O-sialoglycoprotein endopeptidase (OSGE). OSGE treatment also repairs the age-dependent loss of CD69 expression after in vivo activation.
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