ArticleThe Journal of pediatrics2010
Prenatal cocaine exposure related to cortisol stress reactivity in 11-year-old children.
Article in The Journal of pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00059540 (The Maternal Lifestyle Study), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Maternal Lifestyle Study
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- A Systematic Review and Meta-Analysis Investigating the Relationship between Exposures to Chemical and Non-Chemical Stressors during Prenatal Development and Childhood Externalizing Behaviors.International journal of environmental research and public health · 2020Pooled it
- Pooled it
- Article
- Prenatal Substance Exposure.Annual review of developmental psychology · 2023Article
- Prenatal substance exposure, early-life adversity, and parenting: Associations with adolescent stress response.Developmental psychobiology · 2023Article
- Adrenal crisis during pregnancy: Case report and obstetric perspective.Frontiers in medicine · 2022Article
- DNA methylation in children with prenatal methamphetamine exposure and environmental adversity.Pediatric research · 2021Article
- Longitudinal changes of amygdala functional connectivity in adolescents prenatally exposed to cocaine.Drug and alcohol dependence · 2019Article
- Distinctive Mechanisms of Adversity and Socioeconomic Inequality in Child Development: A Review and Recommendations for Evidence-Based Policy.Policy insights from the behavioral and brain sciences · 2017Article
- Prenatal Drug Exposure and Adolescent Cortisol Reactivity: Association with Behavioral Concerns.Journal of developmental and behavioral pediatrics : JDBP · 2016Article
- Parental Substance Abuse As an Early Traumatic Event. Preliminary Findings on Neuropsychological and Personality Functioning in Young Drug Addicts Exposed to Drugs Early.Frontiers in psychology · 2016Article
- Constructing and Adapting Causal and Formative Measures of Family Settings: The HOME Inventory as Illustration.Journal of family theory & review · 2015Article
- Prenatal cocaine exposure differentially affects stress responses in girls and boys: associations with future substance use.Development and psychopathology · 2015Article
- The contributions of early adverse experiences and trajectories of respiratory sinus arrhythmia on the development of neurobehavioral disinhibition among children with prenatal substance exposure.Development and psychopathology · 2014Article
- Prenatal drug exposure moderates the association between stress reactivity and cognitive function in adolescence.Developmental neuroscience · 2014Article
- Translational analysis of effects of prenatal cocaine exposure on human infant cries and rat pup ultrasonic vocalizations.PloS one · 2014Article
- Connectomics signatures of prenatal cocaine exposure affected adolescent brains.Human brain mapping · 2013Article
- Prenatal cocaine exposure alters functional activation in the ventral prefrontal cortex and its structural connectivity with the amygdala.Psychiatry research · 2013Article
- Early adverse care, stress neurobiology, and prevention science: lessons learned.Prevention science : the official journal of the Society for Prevention Research · 2013Article
- Cortisol reactivity in two-year-old children prenatally exposed to methamphetamine.Journal of studies on alcohol and drugs · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveDetermine the association between prenatal cocaine exposure and postnatal environmental adversity on salivary cortisol stress reactivity in school-aged children. STUDY
designSubjects included 743 11-year-old children (n = 320 cocaine-exposed; 423 comparison) followed since birth in a longitudinal prospective multisite study. Saliva samples were collected to measure cortisol at baseline and after a standardized procedure to induce psychological stress. Children were divided into those who showed an increase in cortisol from baseline to post stress and those who showed a decrease or blunted cortisol response. Covariates measured included site, birthweight, maternal pre and postnatal use of alcohol, tobacco or marijuana, social class, changes in caretakers, maternal depression and psychological symptoms, domestic and community violence, child abuse, and quality of the home.
resultsWith adjustment for confounding variables, cortisol reactivity to stress was more likely to be blunted in children with prenatal cocaine exposure. Children exposed to cocaine and who experienced domestic violence showed the strongest effects.
conclusionsThe combination of prenatal cocaine exposure and an adverse postnatal environment could downregulate the hypothalamic-pituitary-adrenal axis resulting in the blunted cortisol response to stress possibly increasing risk for later psychopathology and adult disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.