Evidence map›Paper›PMID 20399926›Full record

ArticleAmerican journal of ophthalmology2010

Four-year incidence and progression of age-related macular degeneration: the Los Angeles Latino Eye Study.

Rohit Varma, Athena W P Foong, Mei-Ying Lai, Farzana Choudhury, Ronald Klein, Stanley P Azen, Los Angeles Latino Eye Study Group

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01272063 (Measurement and Analysis of Macular Retinal Pigment Epithelium), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01272063 completednot on this map

Measurement and Analysis of Macular Retinal Pigment Epithelium (RPE) Elevations With Cirrus HD-OCT vs. Color Fundus Photography

TypeobservationalSponsorCarl Zeiss Meditec, Inc.Ran2010 to 2011Enrolled91ConditionsDrusen Stage Macular Degeneration
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rohit VarmaDoheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. rvarma@usc.edu
Athena W P Foong
Mei-Ying Lai
Farzana Choudhury
Ronald Klein
Stanley P Azen
Los Angeles Latino Eye Study Group
University of Southern California · USUniversity of Wisconsin–Madison · US

Funding

LOS ANGELES LATINO EYE STUDYU10EY011753 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VARMA, ROHIT · 1998 to 2014
$35.6M
VISION RESEARCHP30EY003040 · NEI · DOHENY EYE INSTITUTE · PI SUN, DEMING · 1985 to 2013
$7.0M
NEI NIH HHS EY-03040NEI NIH HHS P30 EY003040NEI NIH HHS U10 EY011753NEI NIH HHS U10-EY-11753
6 · The paper itself

Abstract

purposeTo estimate 4-year incidence and progression of early and advanced age-related macular degeneration (AMD).

designPopulation-based cohort study.

methodsA comprehensive ophthalmologic examination including stereoscopic fundus photography was performed on adult Latinos at baseline and follow-up. Photographs were graded using a modified Wisconsin Age-Related Maculopathy Grading System. For estimations of incidence and progression of AMD, the Age Related Eye Disease Study Scale was used. Main outcome measures are incidence and progression of early AMD (drusen type, drusen size, and retinal pigmentary abnormalities) and advanced AMD (exudative AMD and geographic atrophy).

resultsA total of 4658 of 6100 subjects (76%) completed the follow-up examination. The 4-year incidence of early AMD was 7.5% (95% CI: 6.7, 8.4) and advanced AMD was 0.2% (95% CI: 0.1, 0.4). Progression of any AMD occurred in 9.2% (95% CI: 8.3, 10.1) of at-risk participants. Incidence and progression increased with age. Incidence of early AMD in the second eye (11.2%) was higher than incidence in the first eye (6.9%). Baseline presence of soft indistinct large drusen >or=250 microm in diameter was more likely to predict the 4-year incidence of pigmentary abnormalities, geographic atrophy, and exudative AMD than smaller or hard or soft distinct drusen.

conclusionsAge-specific incidence and progression of AMD in Latinos are lower than in non-Hispanic whites. While incident early AMD is more often unilateral, the risk of its development in the second is higher than in the first eye. Older people and those with soft indistinct large drusen had a higher risk of developing advanced AMD compared to those who were younger and did not have soft indistinct large drusen.

Indexed as

AdultAgedAged, 80 and overAge DistributionCohort StudiesDisease ProgressionFemaleFollow-Up StudiesHispanic or LatinoHumansIncidenceLos AngelesMacular DegenerationMaleMiddle AgedPhotography

Identifiers

PMID20399926
PMCPMC3138505
OpenAlexW2023048107

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.