ArticleMechanisms of ageing and development2010
Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.
Article in Mechanisms of ageing and development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Association of polymorphisms in the beta-2 adrenergic receptor gene with fracture risk and bone mineral density.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Pooled it
- Interactions between social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China.BMC geriatrics · 2013Trial
- G-protein coupled receptors synergy in bone health: new avenues for osteoporosis detection andFrontiers in endocrinology · 2025Review
- Antagonistic Pleiotropy in Human Disease.Journal of molecular evolution · 2020Review
- Genetic variability of five ADRB2 polymorphisms among Mexican Amerindian ethnicities and the Mestizo population.PloS one · 2019Article
- Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.Rejuvenation research · 2015Article
- Unraveling genetic origin of aging-related traits: evolving concepts.Rejuvenation research · 2013Review
- Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- The role of lipid-related genes, aging-related processes, and environment in healthspan.Aging cell · 2013Article
- Genomics of human health and aging.Age (Dordrecht, Netherlands) · 2013Article
- Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations.Rejuvenation research · 2013Article
- Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity.Aging cell · 2012Article
- Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan.Aging cell · 2011Article
- The emergence of human-evolutionary medical genomics.Evolutionary applications · 2011Article
- Evaluation of spirometry values in relation to beta-2-adrenergic receptor gene polymorphism.European journal of medical research · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The Gln(27)Glu polymorphism but not the Arg(16)Gly polymorphism of the beta2-adrenergic receptor (ADRB2) gene appears to be associated with a broad range of aging-associated phenotypes, including cancers at different sites, myocardial infarction (MI), intermittent claudication (IC), and overall/healthy longevity in the Framingham Heart Study Offspring cohort. The Gln(27)Gln genotype increases risks of cancer, MI and IC, whereas the Glu(27) allele or, equivalently, the Gly(16)Glu(27) haplotype tends to be protective against these diseases. Genetic associations with longevity are of opposite nature at young-old and oldest-old ages highlighting the phenomenon of antagonistic pleiotropy. The mechanism of antagonistic pleiotropy is associated with an evolutionary-driven advantage of carriers of a derived Gln(27) allele at younger ages and their survival disadvantage at older ages as a result of increased risks of cancer, MI and IC. The ADRB2 gene can play an important systemic role in healthy aging in evolutionary context that warrants exploration in other populations.
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