ArticleHormones and behavior2010
Methamphetamine enhances paced mating behaviors and neuroplasticity in the medial amygdala of female rats.
Article in Hormones and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
- The median preoptic nucleus is a key site for estradiol regulation of sleep-wake behaviors in females rats.Sleep · 2026Article
- The Median Preoptic Nucleus is a Key Site for Estradiol Regulation of Sleep-Wake Behaviors in Females Rats.bioRxiv : the preprint server for biology · 2025Article
- Being friendly: paced mating for the study of physiological, behavioral, and neuroplastic changes induced by sexual behavior in females.Frontiers in behavioral neuroscience · 2023Review
- Estradiol influences adenosinergic signaling and nonrapid eye movement sleep need in adult female rats.Sleep · 2022Article
- Sex, Drugs, and the Medial Amygdala: A Model of Enhanced Sexual Motivation in the Female Rat.Frontiers in behavioral neuroscience · 2019Article
- Methamphetamine alters DNMT and HDAC activity in the posterior dorsal medial amygdala in an ovarian steroid-dependent manner.Neuroscience letters · 2018Article
- The Role of Ovarian Hormones and the Medial Amygdala in Sexual Motivation.Current sexual health reports · 2017Article
- Methamphetamine and Ovarian Steroid Responsive Cells in the Posteriodorsal Medial Amygdala are Required for Methamphetamine-enhanced Proceptive Behaviors.Scientific reports · 2017Article
- Androgen-primed castrate males are sufficient for methamphetamine-facilitated increases in proceptive behavior in female rats.Hormones and behavior · 2016Article
- Methamphetamine-enhanced female sexual motivation is dependent on dopamine and progesterone signaling in the medial amygdala.Hormones and behavior · 2015Article
- Involvement of pregnane xenobiotic receptor in mating-induced allopregnanolone formation in the midbrain and hippocampus and brain-derived neurotrophic factor in the hippocampus among female rats.Psychopharmacology · 2014Article
- Animal Models for the Study of Female Sexual Dysfunction.Sexual medicine reviews · 2013Review
- Differential responses of hippocampal neurons and astrocytes to nicotine and hypoxia in the fetal guinea pig.Neurotoxicity research · 2013Article
- Chronic pre-exposure to methamphetamine following 31 days of withdrawal impairs sexual performance but not sexual conditioning in male Japanese quail.Behavioural processes · 2012Article
- Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis.Biology of sex differences · 2012Article
- The unrealized potential of addiction science in curbing the HIV epidemic.Current HIV research · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Methamphetamine (METH) is a psychomotor stimulant strongly associated with increases in sexual drive and behavior in women and men. Even though men and women are equally as likely to be addicted to or use METH, studies of sexual behavior often focus on male users. The paucity in studies examining the effect of METH in women is of great concern, when one considers the high correlation with sexually transmitted diseases such as HIV/AIDS and unplanned pregnancies. In fact, why METH so profoundly increases sexual drive is unknown. We have demonstrated that repeated exposure to METH enhances both receptivity and proceptivity in hormonally primed female rats. The current study examined whether a repeated exposure to METH enhanced female-initiated sexual behaviors in hormonally primed rats. In a paced mating paradigm, METH treatment significantly decreased the female's return latency following a mount (57%) and an ejaculation (44%), and the likelihood to leave the male following an intromission (37%) compared to controls. The METH-induced changes in paced mating behavior were accompanied by a 60% increase in spinophilin levels in the medial amygdala following hormonal priming and METH treatment. Taken together, these findings suggest that METH increases female sexual motivation and behavior in the rat potentially via changes in the neural substrate that require repeated exposure to the drug.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.