ReviewCurrent opinion in pharmacology2010
Neuropeptides: keeping the balance between pathogen immunity and immune tolerance.
Review in Current opinion in pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Neuroimmune circuits in respiratory pathophysiology: decoding molecular crosstalk for precision therapeutic targeting.Annals of medicine · 2026Review
- Neuropeptides in the Management of Alzheimer's Disease: From Pathophysiology to Therapeutic Opportunities.International journal of molecular sciences · 2026Review
- Tachykinin-related peptide signalling is important for the immune response of the mealworm beetleFrontiers in immunology · 2026Article
- Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death.Biomolecules · 2024Review
- Article
- Peripheral neuroimmune interactions: selected review and some clinical implications.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Review
- Mammalian Neuropeptides as Modulators of Microbial Infections: Their Dual Role in Defense versus Virulence and Pathogenesis.International journal of molecular sciences · 2021Review
- Article
- Microbiota and gut neuropeptides: a dual action of antimicrobial activity and neuroimmune response.Psychopharmacology · 2019Review
- Neuropeptides SP and CGRP Diminish theMediators of inflammation · 2018Article
- VIP boosts regulatory T cell induction by trophoblast cells in an in vitro model of trophoblast-maternal leukocyte interaction.Journal of leukocyte biology · 2015Article
- The neuropeptide vasoactive intestinal peptide: direct effects on immune cells and involvement in inflammatory and autoimmune diseases.Acta physiologica (Oxford, England) · 2015Review
- Diabetes tolerogenic vaccines targeting antigen-specific inflammation.Human vaccines & immunotherapeutics · 2015Review
- Biomarkers predicting a need for intensive treatment in patients with early arthritis.Current pharmaceutical design · 2015Review
- Review
- Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders, and Microglia.Frontiers in integrative neuroscience · 2013Article
- Defects in the vasoactive intestinal peptide (VIP)/VPAC system during early stages of the placental-maternal leucocyte interaction impair the maternal tolerogenic response.Clinical and experimental immunology · 2012Article
- Vasoactive intestinal peptide/vasoactive intestinal peptide receptor relative expression in salivary glands as one endogenous modulator of acinar cell apoptosis in a murine model of Sjögren's syndrome.Clinical and experimental immunology · 2011Article
- Inflammation and the nervous system: the connection in the cornea in patients with infectious keratitis.Investigative ophthalmology & visual science · 2011Article
- NOP Receptor Ligands as Potential Agents for Inflammatory and Autoimmune Diseases.Journal of amino acids · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Various neuropeptides have emerged recently as potent immunomodulatory factors with potential for their therapeutic use in immune disorders. Here we highlight the most recent data relevant in the field and we offer our opinion on how neuropeptide therapy might impact clinical immune diseases, and the challenges in this field that must be overcome before achieving medical progress. We also review recent reports describing the antimicrobial effects showed by some neuropeptides and the therapeutic, physiological, and evolutionary consequences of this new finding. Finally, we discuss how a physiologically functional neuropeptide system contributes to general health and how neuropeptides educate our immune system to be tolerant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.