ArticleThe American journal of medicine2010
Lung function in young adults predicts airflow obstruction 20 years later.
Article in The American journal of medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development.American journal of respiratory and critical care medicine · 2011Trial
- From ideal respiratory health to chronic lung disease: indicators of impaired respiratory health.Expert review of respiratory medicine · 2026Review
- Progenitor Resilience and the Early Onset of Chronic Lung Diseases: NHLBI workshop report.American journal of respiratory cell and molecular biology · 2026Article
- Adult life course trajectories of lung function and the development of interstitial lung abnormalities: the CARDIA lung study.Respiratory research · 2026Article
- Ozone and childhood respiratory health: A primer for US pediatric providers and a call for a more protective standard.Pediatric pulmonology · 2023Review
- Cardiovascular Morbidity in Individuals with Impaired FEV1.Current cardiology reports · 2022Review
- The Coronary Artery Risk Development In Young Adults (CARDIA) Study: JACC Focus Seminar 8/8.Journal of the American College of Cardiology · 2021Review
- Article
- Effect of tiger milk mushroom (Lignosus rhinocerus) supplementation on respiratory health, immunity and antioxidant status: an open-label prospective study.Scientific reports · 2021Article
- Longitudinal Associations of Fitness and Obesity in Young Adulthood With Right Ventricular Function and Pulmonary Artery Systolic Pressure in Middle Age: The CARDIA Study.Journal of the American Heart Association · 2021Article
- Childhood Origins of Adult Lung Disease as Opportunities for Prevention.The journal of allergy and clinical immunology. In practice · 2020Article
- Adult Life-Course Trajectories of Lung Function and the Development of Emphysema: The CARDIA Lung Study.The American journal of medicine · 2020Article
- A Genetic Risk Score Associated with Chronic Obstructive Pulmonary Disease Susceptibility and Lung Structure on Computed Tomography.American journal of respiratory and critical care medicine · 2019Article
- Article
- Lung Function in Young Adults and Risk of Cardiovascular Events Over 29 Years: The CARDIA Study.Journal of the American Heart Association · 2018Article
- Defining Impaired Respiratory Health. A Paradigm Shift for Pulmonary Medicine.American journal of respiratory and critical care medicine · 2018Review
- Lung function in adults born preterm.PloS one · 2018Article
- Childhood asthma is a risk factor for the development of chronic obstructive pulmonary disease.Current opinion in allergy and clinical immunology · 2017Review
- The ordinary work environment increases symptoms from eyes and airways in mild steel welders.International archives of occupational and environmental health · 2015Article
- Admixture mapping identifies a quantitative trait locus associated with FEV1/FVC in the COPDGene Study.Genetic epidemiology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveThe burden of obstructive lung disease is increasing, yet there are limited data on its natural history in young adults. To determine in a prospective cohort of generally healthy young adults the influence of early adult lung function on the presence of airflow obstruction in middle age.
methodsA longitudinal study was performed of 2496 adults who were 18 to 30 years of age at entry, did not report having asthma, and returned at year 20. Airflow obstruction was defined as an forced expiratory volume in 1 second/forced vital capacity ratio less than the lower limit of normal.
resultsAirflow obstruction was present in 6.9% and 7.8% of participants at years 0 and 20, respectively. Less than 10% of participants with airflow obstruction self-reported chronic obstructive pulmonary disease. In cross-sectional analyses, airflow obstruction was associated with less education, smoking, and self-reported chronic obstructive pulmonary disease. Low forced expiratory volume in 1 second, forced expiratory volume in 1 second/forced vital capacity ratio, and airflow obstruction in young adults were associated with low lung function and airflow obstruction 20 years later. Of those with airflow obstruction at year 0, 52% had airflow obstruction 20 years later. The forced expiratory volume in 1 second/forced vital capacity at year 0 was highly predictive of airflow obstruction 20 years later (c-statistic 0.91; 95% confidence interval, 0.89-0.93). The effect of cigarette smoking on lung function decline with age was most evident in young adults with preexisting airflow obstruction.
conclusionAirflow obstruction is mostly unrecognized in young and middle-aged adults. Low forced expiratory volume in 1 second, low forced expiratory volume in 1 second/forced vital capacity ratio, airflow obstruction in young adults, and smoking are highly predictive of low lung function and airflow obstruction in middle age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.