ArticlePeptides2010
Chronic sugar intake dampens feeding-related activity of neurons synthesizing a satiety mediator, oxytocin.
Article in Peptides, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- Trial
- Paraventricular oxytocin neurons impact energy intake and expenditure: projections to the bed nucleus of the stria terminalis reduce sucrose consumption.Frontiers in endocrinology · 2024Article
- Do oxytocin neurones affect feeding?Journal of neuroendocrinology · 2021Review
- Oxytocin and Food Intake Control: Neural, Behavioral, and Signaling Mechanisms.International journal of molecular sciences · 2021Review
- Oxytocin: A Potential Therapeutic for Obesity.Journal of obesity & metabolic syndrome · 2021Review
- The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis.Journal of neuroendocrinology · 2020Review
- Excessive Consumption of Sugar: an Insatiable Drive for Reward.Current nutrition reports · 2019Review
- Effect of Oxytocin on Hunger Discrimination.Frontiers in endocrinology · 2019Article
- Intra-accumbens Raclopride Administration Prevents Behavioral Changes Induced by Intermittent Access to Sucrose Solution.Frontiers in neuroscience · 2018Article
- Polymorphisms of the oxytocin receptor gene and overeating: the intermediary role of endophenotypic risk factors.Nutrition & diabetes · 2017Article
- Sex-specific effects of relaxin-3 on food intake and body weight gain.British journal of pharmacology · 2017Review
- Recent studies of the effects of sugars on brain systems involved in energy balance and reward: Relevance to low calorie sweeteners.Physiology & behavior · 2016Review
- Peripheral oxytocin administration reduces ethanol consumption in rats.Pharmacology, biochemistry, and behavior · 2016Article
- A refined high carbohydrate diet is associated with changes in the serotonin pathway and visceral obesity.Genetics research · 2015Article
- Central oxytocin and food intake: focus on macronutrient-driven reward.Frontiers in endocrinology · 2015Review
- Common effects of fat, ethanol, and nicotine on enkephalin in discrete areas of the brain.Neuroscience · 2014Article
- Supraoptic oxytocin and vasopressin neurons function as glucose and metabolic sensors.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Role of oxytocin signaling in the regulation of body weight.Reviews in endocrine & metabolic disorders · 2013Review
- The contribution of brain reward circuits to the obesity epidemic.Neuroscience and biobehavioral reviews · 2013Review
- Oxytocin reduces reward-driven food intake in humans.Diabetes · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Increased tone of orexigens mediating reward occurs upon repeated consumption of sweet foods. Interestingly, some of these reward orexigens, such as opioids, diminish activity of neurons synthesizing oxytocin, a nonapeptide that promotes satiety and feeding termination. It is not known, however, whether consumption-related activity of the central oxytocin system is modified under chronic sugar feeding reward itself. Therefore, we examined how chronic consumption of a rewarding high-sucrose (HS) vs. bland cornstarch (CS) diet affected the activity of oxytocin cells in the hypothalamus at the time of meal termination. Schedule-fed (2h/day) rats received either a HS or CS powdered diet for 20 days. On the 21st day, they were given the same or the opposite diet, and food was removed after the main consummatory activity was completed. Animals were perfused 60 min after feeding termination and brains were immunostained for oxytocin and the marker of neuronal activity, c-Fos. The percentage of c-Fos-positive oxytocin cells in the hypothalamic paraventricular nucleus was significantly lower in rats chronically exposed to the HS than to the CS diet, regardless of which diet they received on the final day. A similar pattern was observed in the supraoptic nucleus. We conclude that the chronic rather than acute sucrose intake reduces activity of the anorexigenic oxytocin system. These findings indicate that chronic consumption of sugar blunts activity of pathways that mediate satiety. We speculate that a reduction in central satiety signaling precipitated by regular intake of foods high in sugar may lead to generalized overeating.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.