ArticleActa biomaterialia2010
Regulation of keratinocyte signaling and function via changes in epidermal growth factor presentation.
Article in Acta biomaterialia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
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- Masterful macrophages: understanding and targeting activation dysfunction in diabetic wounds.Burns & trauma · 2025Review
- Growth factors IGF-1 and KGF and adipose-derived stem cells promote migration and viability of primary human keratinocytes in anFrontiers in medicine · 2025Article
- Immunomodulatory Effect of Epidermal Growth Factor Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells on Atopic Dermatitis.International journal of stem cells · 2022Article
- Statistic Copolymers Working as Growth Factor-Binding Mimics of Fibronectin.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Chemical Composition ofPlants (Basel, Switzerland) · 2022Article
- Design and implementation of a microfluidic device capable of temporal growth factor delivery reveal filtering capabilities of the EGFR/ERK pathway.APL bioengineering · 2021Article
- Development of an Aged Full-Thickness Skin Model Using Flexible Skin-on-a-Chip Subjected to Mechanical Stimulus Reflecting the Circadian Rhythm.International journal of molecular sciences · 2021Article
- VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes.NPJ Regenerative medicine · 2021Article
- Leader cell PLCγ1 activation during keratinocyte collective migration is induced by EGFR localization and clustering.Bioengineering & translational medicine · 2019Article
- Engineering Approaches to Study Cellular Decision Making.Annual review of biomedical engineering · 2018Review
- Adipose Derived Stem Cells for Corneal Wound Healing after Laser Induced Corneal Lesions in Mice.Journal of clinical medicine · 2017Article
- Immobilized epidermal growth factor stimulates persistent, directed keratinocyte migration via activation of PLCγ1.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Hierarchy of cellular decisions in collective behavior: Implications for wound healing.Scientific reports · 2016Article
- The Roles of Growth Factors in Keratinocyte Migration.Advances in wound care · 2015Review
- The use of native chemical functional groups presented by wound beds for the covalent attachment of polymeric microcarriers of bioactive factors.Biomaterials · 2013Article
- Asymmetric migration of human keratinocytes under mechanical stretch and cocultured fibroblasts in a wound repair model.PloS one · 2013Article
- A material's point of view on recent developments of polymeric biomaterials: control of mechanical and biochemical properties.Journal of materials chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Motivated by the need for bioactive materials that can accelerate dermal wound healing, this work describes the responses of keratinocytes to covalently immobilized epidermal growth factor (EGF) and how differences in the physical presentation of this growth factor affect cell function. Specifically, human keratinocytes were cultured with EGF delivered in soluble form, immobilized in a homogeneous pattern or immobilized in a gradient pattern, followed by analysis of cellular signaling, proliferation and migration. By changing the manner in which EGF was presented, keratinocyte behavior was dramatically altered. Keratinocytes responded to immobilized EGF patterns with high EGF receptor (EGFR) but low ERK1/2 and Akt phosphorylation, accompanied by low proliferation, high migratory activity and coordinated cell alignment. In contrast, keratinocytes treated with soluble EGF experienced lower EGFR but higher ERK1/2 and Akt phosphorylation and displayed a highly proliferative, rather than migratory, phenotype. Keratinocytes also responded to differences in immobilized EGF patterns, as migration was fastest upon immobilized gradients of EGF. A better understanding the interaction of cells with soluble vs. immobilized growth factors can help elucidate native healing events and achieve greater control over cell function, which may be useful in the development of wound repair treatments for many types of tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.