ReviewNeuroscience and biobehavioral reviews2010
Cross-species assessments of motor and exploratory behavior related to bipolar disorder.
Review in Neuroscience and biobehavioral reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 65 citations in OpenAlex.
- Modafinil improves attentional performance in healthy, non-sleep deprived humans at doses not inducing hyperarousal across species.Neuropharmacology · 2017Trial
- Quantifying Exploratory Behavior In The Human Behavioral Pattern Monitor Using Automated Video Tracking.Methods in Psychology (Online) · 2025Article
- A Computational Ethology Approach for Characterizing Behavioral Dynamics in Bipolar Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Towards a characterization of human spatial exploration behavior.Behavior research methods · 2025Article
- Cataleptogenic Effect of Haloperidol Formulated in Water-Soluble Calixarene-Based Nanoparticles.Pharmaceutics · 2023Article
- Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes.Communications biology · 2022Article
- Locus coeruleus activation during environmental novelty gates cocaine-induced long-term hyperactivity of dopamine neurons.iScience · 2022Article
- Use of Actigraphy for a Rat Behavioural Sleep Study.Clocks & sleep · 2021Article
- The effect of piracetam on behavioral reactions of adult rats and morphological changes in the brain after whole body fractionated gamma irradiation: an exploratory study.Radiation and environmental biophysics · 2021Article
- Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats.Molecular psychiatry · 2020Article
- Motion mapping in humans as a biomarker for psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers.JCI insight · 2017Article
- Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Systematically characterizing dysfunctional long intergenic non-coding RNAs in multiple brain regions of major psychosis.Oncotarget · 2016Article
- Animal models of bipolar mania: The past, present and future.Neuroscience · 2016Review
- Modeling mania in preclinical settings: A comprehensive review.Progress in neuro-psychopharmacology & biological psychiatry · 2016Review
- Investigating the underlying mechanisms of aberrant behaviors in bipolar disorder from patients to models: Rodent and human studies.Neuroscience and biobehavioral reviews · 2015Review
- Modeling bipolar disorder in mice by increasing acetylcholine or dopamine: chronic lithium treats most, but not all features.Psychopharmacology · 2015Article
- The catecholaminergic-cholinergic balance hypothesis of bipolar disorder revisited.European journal of pharmacology · 2015Review
- The modified hole board--measuring behavior, cognition and social interaction in mice and rats.Journal of visualized experiments : JoVE · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Alterations in exploratory behavior are a fundamental feature of bipolar mania, typically characterized as motor hyperactivity and increased goal-directed behavior in response to environmental cues. In contrast, abnormal exploration associated with schizophrenia and depression can manifest as prominent withdrawal, limited motor activity, and inattention to the environment. While motor abnormalities are cited frequently as clinical manifestations of these disorders, relatively few empirical studies have quantified human exploratory behavior. This article reviews the literature characterizing motor and exploratory behavior associated with bipolar disorder and genetic and pharmacological animal models of the illness. Despite sophisticated assessment of exploratory behavior in rodents, objective quantification of human motor activity has been limited primarily to actigraphy studies with poor cross-species translational value. Furthermore, symptoms that reflect the cardinal features of bipolar disorder have proven difficult to establish in putative animal models of this illness. Recently, however, novel tools such as the human behavioral pattern monitor provide multivariate translational measures of motor and exploratory activity, enabling improved understanding of the neurobiology underlying psychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.