ArticleJournal of molecular biology2010
Multi-domain packing in the aminoacylatable 3' end of a plant viral RNA.
Article in Journal of molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Host-like RNA Elements Regulate Virus Translation.Viruses · 2024Review
- Structural diversity and phylogenetic distribution of valyl tRNA-like structures in viruses.RNA (New York, N.Y.) · 2021Article
- Crystal structures of an unmodified bacterial tRNA reveal intrinsic structural flexibility and plasticity as general properties of unbound tRNAs.RNA (New York, N.Y.) · 2020Article
- Viral RNA structure-based strategies to manipulate translation.Nature reviews. Microbiology · 2019Review
- Ribosome-induced RNA conformational changes in a viral 3'-UTR sense and regulate translation levels.Nature communications · 2018Article
- A Survey of DDX21 Activity During Rev/RRE Complex Formation.Journal of molecular biology · 2018Article
- A DEAD-box protein acts through RNA to promote HIV-1 Rev-RRE assembly.Nucleic acids research · 2017Article
- A DEAD-Box Helicase Mediates an RNA Structural Transition in the HIV-1 Rev Response Element.Journal of molecular biology · 2017Article
- Analysis of RNA structure using small-angle X-ray scattering.Methods (San Diego, Calif.) · 2017Article
- Progress and outlook in structural biology of large viral RNAs.Virus research · 2014Review
- An RNA tertiary switch by modifying how helices are tethered.Genome biology · 2014Article
- The structural basis of transfer RNA mimicry and conformational plasticity by a viral RNA.Nature · 2014Article
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- Structural architecture of an RNA that competitively inhibits RNase L.RNA (New York, N.Y.) · 2012Article
- A conserved RNA pseudoknot in a putative molecular switch domain of the 3'-untranslated region of coronaviruses is only marginally stable.RNA (New York, N.Y.) · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Turnip yellow mosaic virus (TYMV) contains a tRNA-like structure (TLS) in its 3' untranslated region (3' UTR). This highly structured element induces valylation of the viral RNA by host cell enzymes and is important for virus proliferation. Directly upstream of the TYMV TLS is an upstream pseudoknot domain (UPD) that has been considered to be structurally distinct from the TLS. However, using a combination of functional, biochemical, and biophysical assays, we show that the entire 3' UTR of the viral genome is a single structured element in the absence of cellular protein. This packing architecture stabilizes the RNA structure and creates a better substrate for aminoacylation, and thus the UPD and TLS are functionally and structurally coupled. It has been proposed that the TYMV TLS acts as a molecular switch between translation and replication. Our results suggest that this putative switch could be based on structural changes within the global architecture of the UTR induced by interactions with the ribosome. The TYMV TLS.UPD might demonstrate how RNA structural plasticity can play a role in regulation of biological processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.