ArticleThe British journal of nutrition2010
Biochemical risk indices, including plasma homocysteine, that prospectively predict mortality in older British people: the National Diet and Nutrition Survey of People Aged 65 Years and Over.
Article in The British journal of nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Pooled it
- Dietary intake of total, animal, and plant proteins and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies.BMJ (Clinical research ed.) · 2020Pooled it
- Dietary protein intake and all-cause and cause-specific mortality: results from the Rotterdam Study and a meta-analysis of prospective cohort studies.European journal of epidemiology · 2020Pooled it
- Metformin Treatment and Homocysteine: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Nutrients · 2016Pooled it
- Vitamin B-6 and riboflavin, their metabolic interaction, and relationship with MTHFR genotype in adults aged 18-102 years.The American journal of clinical nutrition · 2022Trial
- Effects of Two-Year Vitamin BNutrients · 2016Trial
- Riboflavin Deficiency Is Highly Prevalent in Females and Children across High and Low/Middle Income Countries Worldwide.The Journal of nutrition · 2026Article
- Dietary amino acids intake and all-cause and cause-specific mortality: results from the Golestan Cohort Study.Nutrition journal · 2024Article
- Betaine as a Functional Ingredient: Metabolism, Health-Promoting Attributes, Food Sources, Applications and Analysis Methods.Molecules (Basel, Switzerland) · 2023Review
- Animal Protein Intake Is Inversely Associated With Mortality in Older Adults: The InCHIANTI Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Serum folate deficiency and the risks of dementia and all-cause mortality: a national study of old age.Evidence-based mental health · 2022Article
- A probability formula derived from serum indicators, age, and comorbidities as an early predictor of dementia in elderly Chinese people.Brain and behavior · 2021Article
- Homocysteine, Folic Acid, Cyanocobalamin, and Frailty in Older People: Findings From the "Invece. Ab" Study.Frontiers in physiology · 2021Article
- The relationship between the concentration of plasma homocysteine and chronic kidney disease: a cross sectional study of a large cohort.Journal of nephrology · 2019Article
- High Protein Intake Is Associated with Lower Risk of All-Cause Mortality in Community-Dwelling Chinese Older Men and Women.The journal of nutrition, health & aging · 2019Article
- Serum Homocysteine Levels Had Important Associations with Activity and Quality of Daily Living in Chinese Centenarians.The journal of nutrition, health & aging · 2019Article
- Review
- Homocysteinemia and early outcome of acute ischemic stroke in elderly patients.Brain and behavior · 2016Article
- Association between serum homocysteine and arterial stiffness in elderly: a community-based study.Journal of geriatric cardiology : JGC · 2014Article
- Health effects of protein intake in healthy elderly populations: a systematic literature review.Food & nutrition research · 2014Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Predictive power, for total and vascular mortality, of selected indices measured at baseline in the British National Diet and Nutrition Survey (community-living subset) of People Aged 65 Years and Over was tested. Mortality status and its primary and underlying causes were recorded for 1100 (mean age 76.7 (sd 7.5) years, 50.2% females) respondents from the baseline survey in 1994-5 until September 2008. Follow-up data analyses focussed especially on known predictors of vascular disease risk, together with intakes and status indices of selected nutrients known to affect, or to be affected by, these predictors. Total mortality was significantly predicted by hazard ratios of baseline plasma concentrations (per sd) of total homocysteine (tHcy) (95% CI) 1.19 (1.11, 1.27), pyridoxal phosphate 0.90 (0.81, 1.00), pyridoxic acid 1.10 (1.03, 1.19), alpha1-antichymotrypsin 1.21 (1.13, 1.29), fibrinogen 1.14 (1.05, 1.23), creatinine 1.20 (1.10, 1.31) and glycosylated Hb 1.23 (1.14, 1.32), and by dietary intakes of energy 0.87 (0.80, 0.96) and protein 0.86 (0.77, 0.97). Prediction patterns and significance were similar for primary-cause vascular mortality. The traditional risk predictors plasma total and HDL cholesterol were not significant mortality predictors in this age group, nor were the known tHcy-regulating nutrients, folate and vitamin B12 (intakes and status indices). Model adjustment for known risk predictors resulted in the loss of significance for some of the afore-mentioned indices; however, tHcy 1.34 (1.04, 1.73) remained a significant predictor for vascular mortality. Thus, total and primary vascular mortality is predicted by energy and protein intakes, and by biochemical indices including tHcy, independent of serum folate or vitamin B12.
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