ArticleParasites & vectors2010
Parasitic manipulation and neuroinflammation: Evidence from the system Microphallus papillorobustus (Trematoda) - Gammarus (Crustacea).
Article in Parasites & vectors, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Parasite-Induced Changes in the Nervous System of the Shore CrabInternational journal of molecular sciences · 2026Article
- The caterpillar Manduca sexta brain shows changes in gene expression and protein abundance correlating with parasitic manipulation of behaviour.Scientific reports · 2024Article
- Adaptive host responses to infection can resemble parasitic manipulation.Ecology and evolution · 2023Article
- Parasite infection and the movement of the aquatic snailEcology and evolution · 2023Article
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- Invasion history shapes host transcriptomic response to a body-snatching parasite.Molecular ecology · 2021Article
- Insect Behavioral Change and the Potential Contributions of Neuroinflammation-A Call for Future Research.Genes · 2021Review
- Gene Duplication and Gain in the Trematode Atriophallophorus winterbourni Contributes to Adaptation to Parasitism.Genome biology and evolution · 2021Article
- High parasite diversity in the amphipodEcology and evolution · 2020Article
- Immunity, host physiology, and behaviour in infected vectors.Current opinion in insect science · 2017Review
- Position of larval tapeworms, Polypocephalus sp., in the ganglia of shrimp, Litopenaeus setiferus.Integrative and comparative biology · 2014Article
- A trematode parasite alters growth, feeding behavior, and demographic success of invasive rusty crayfish (Orconectes rusticus).Oecologia · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuropathological consequences of neuroinflammatory processes have been implicated in a wide range of diseases affecting the central nervous system (CNS). Glial cells, the resident immune cells of the CNS, respond to tissue injury by releasing proinflammatory cytokines and free radicals such as nitric oxide. We explored the possibility that neuroimmune responses are involved in parasitic manipulation of host behavior in a trematode-crustacean association. The cerebral larva of the flatworm Microphallus papillorobustus alters responses to environmental stimuli - and thus reflex pathways - in the crustacean Gammarus insensibilis, in a way that enhances predation of the crustacean by birds, definitive hosts of the parasite.
resultsImmunocytochemical experiments followed by confocal microscopy were performed to study the distribution of glutamine synthetase, a glial cell marker, and nitric oxide synthase in the brain of gammarids. Astrocyte-like glia and their processes were abundant at the surface of the parasites while levels of nitric oxide synthase were elevated at the host-parasite interface in the brain of gammarids harboring mature cerebral larvae and demonstrating altered behavior.
conclusionTaken together these results lend support to the neuroinflammation hypothesis whereby a chronic CNS specific immune response induced by the parasite plays a role in the disruption of neuromodulation, neuronal integrity, and behavior in infected hosts.
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Registered trials
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