ArticleActa veterinaria Scandinavica2010
Variant -and individual dependent nature of persistent Anaplasma phagocytophilum infection.
Article in Acta veterinaria Scandinavica, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 35 citations in OpenAlex.
- Microorganisms inInternational journal for parasitology. Parasites and wildlife · 2026Article
- Article
- ExperimentalFrontiers in veterinary science · 2020Article
- A review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe.Parasites & vectors · 2019Review
- Prevalence and co-infection with tick-borneInternational journal for parasitology. Parasites and wildlife · 2019Article
- Intrauterine Transmission of Anaplasma phagocytophilum in Persistently Infected Lambs.Veterinary sciences · 2018Article
- Anaplasma marginale and Anaplasma phagocytophilum: Rickettsiales pathogens of veterinary and public health significance.Parasitology research · 2015Review
- Lambs immunized with an inactivated variant of Anaplasma phagocytophilum.Acta veterinaria Scandinavica · 2015Article
- Essential domains of Anaplasma phagocytophilum invasins utilized to infect mammalian host cells.PLoS pathogens · 2015Article
- Temporal and spatial variation in Anaplasma phagocytophilum infection in Swedish moose (Alces alces).Epidemiology and infection · 2014Article
- Prevalence and Diversity among Anaplasma phagocytophilum Strains Originating from Ixodes ricinus Ticks from Northwest Norway.Journal of pathogens · 2014Article
- Analysis of the population structure of Anaplasma phagocytophilum using multilocus sequence typing.PloS one · 2014Article
- Anaplasma phagocytophilum--a widespread multi-host pathogen with highly adaptive strategies.Frontiers in cellular and infection microbiology · 2013Review
- Structure of the type IV secretion system in different strains of Anaplasma phagocytophilum.BMC genomics · 2012Article
- Longitudinal field study on bovine Babesia spp. and Anaplasma phagocytophilum infections during a grazing season in Belgium.Parasitology research · 2012Article
- Genetic variants of Anaplasma phagocytophilum from 14 equine granulocytic anaplasmosis cases.Parasites & vectors · 2011Article
- Prevalence of Anaplasma phagocytophilum infection and effect on lamb growth.Acta veterinaria Scandinavica · 2011Article
- A comparative study of clinical manifestations, haematological and serological responses after experimental infection with Anaplasma phagocytophilum in two Norwegian sheep breeds.Acta veterinaria Scandinavica · 2011Article
- Anaplasma phagocytophilum infection in a domestic cat in Finland: Case report.Acta veterinaria Scandinavica · 2010Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnaplasma phagocytophilum is the causative agent of tick-borne fever in ruminants and human granulocytotropic anaplasmosis (HGA). The bacterium is able to survive for several months in immune-competent sheep by modifying important cellular and humoral defence mechanisms. Little is known about how different strains of A. phagocytophilum propagate in their natural hosts during persistent infection.
methodsTwo groups of five lambs were infected with each of two 16S rRNA gene variants of A. phagocytophilum, i.e. 16S variant 1 which is identical to GenBank no M73220 and 16S variant 2 which is identical to GenBank no AF336220, respectively. The lambs were infected intravenously and followed by blood sampling for six months. A. phagocytophilum infection in the peripheral blood was detected by absolute quantitative real-time PCR.
resultsBoth 16S rRNA gene variants of A. phagocytophilum established persistent infection for at least six months and showed cyclic bacteraemias, but variant 1 introduced more frequent periods of bacteraemia and higher number of organisms than 16S rRNA gene variant 2 in the peripheral blood.
conclusionOrganisms were available from blood more or less constantly during the persistent infection and there were individual differences in cyclic activity of A. phagocytophilum in the infected animals. Two 16S rRNA gene variants of A. phagocytophilum show differences in cyclic activity during persistent infection in lambs.
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