ArticleMolecular microbiology2010
Amino-terminal residues dictate the export efficiency of the Campylobacter jejuni filament proteins via the flagellum.
Article in Molecular microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Campylobacter jejuni regulates cell cycle progression to potentiate host cell invasion.Cell communication and signaling : CCS · 2025Article
- Campylobacter jejuni: targeting host cells, adhesion, invasion, and survival.Applied microbiology and biotechnology · 2023Review
- Molecular Dissection of theMicroorganisms · 2020Article
- Quantification of serine protease HtrA molecules secreted by the foodborne pathogenGut pathogens · 2019Article
- Importance ofFrontiers in microbiology · 2017Article
- Use of a Novel Report Protein to Study the Secretion Signal of Flagellin in Bacillus subtilis.Current microbiology · 2016Article
- Secretion of Flagellar Proteins by the Pseudomonas aeruginosa Type III Secretion-Injectisome System.Journal of bacteriology · 2015Article
- Campylobacter jejuni serine protease HtrA plays an important role in heat tolerance, oxygen resistance, host cell adhesion, invasion, and transmigration.European journal of microbiology & immunology · 2015Article
- Flagellar biosynthesis exerts temporal regulation of secretion of specific Campylobacter jejuni colonization and virulence determinants.Molecular microbiology · 2014Article
- Two residues predominantly dictate functional difference in motility between Shewanella oneidensis flagellins FlaA and FlaB.The Journal of biological chemistry · 2014Article
- Extracellular secretion of protease HtrA from Campylobacter jejuni is highly efficient and independent of its protease activity and flagellum.European journal of microbiology & immunology · 2013Article
- Xenocin export by the flagellar type III pathway in Xenorhabdus nematophila.Journal of bacteriology · 2013Article
- Host epithelial cell invasion by Campylobacter jejuni: trigger or zipper mechanism?Frontiers in cellular and infection microbiology · 2012Review
- Production of organic acids by probiotic lactobacilli can be used to reduce pathogen load in poultry.PloS one · 2012Article
- The Campylobacter jejuni CiaC virulence protein is secreted from the flagellum and delivered to the cytosol of host cells.Frontiers in cellular and infection microbiology · 2012Article
- Colonization factors of Campylobacter jejuni in the chicken gut.Veterinary research · 2011Review
- Campylobacter jejuni survival within human epithelial cells is enhanced by the secreted protein CiaI.Molecular microbiology · 2011Article
- Genetic and molecular characterization of flagellar assembly in Shewanella oneidensis.PloS one · 2011Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Bacterial flagella play an essential role in the pathogenesis of numerous enteric pathogens. The flagellum is required for motility, colonization, and in some instances, for the secretion of effector proteins. In contrast to the intensively studied flagella of Escherichia coli and Salmonella typhimurium, the flagella of Campylobacter jejuni, Helicobacter pylori and Vibrio cholerae are less well characterized and composed of multiple flagellin subunits. This study was performed to gain a better understanding of flagellin export from the flagellar type III secretion apparatus of C. jejuni. The flagellar filament of C. jejuni is comprised of two flagellins termed FlaA and FlaB. We demonstrate that the amino-termini of FlaA and FlaB determine the length of the flagellum and motility of C. jejuni. We also demonstrate that protein-specific residues in the amino-terminus of FlaA and FlaB dictate export efficiency from the flagellar type III secretion system (T3SS) of Yersinia enterocolitica. These findings demonstrate that key residues within the amino-termini of two nearly identical proteins influence protein export efficiency, and that the mechanism governing the efficiency of protein export is conserved among two pathogens belonging to distinct bacterial classes. These findings are of additional interest because C. jejuni utilizes the flagellum to export virulence proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.