Evidence map›Paper›PMID 20397258›Full record

ReviewWorld journal of gastroenterology2010

Risk factors in familial forms of celiac disease.

Hugh James Freeman

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 44 citations in OpenAlex.

  1. Limited Availability and Higher Cost of Gluten-Free Foods Continue in the United Kingdom: A Comparative Follow-Up Over More Than a Decade.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Article
  2. Review
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  10. Postpartum onset of adult celiac disease in identical twin sisters.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2012
    Article
  11. Article
  12. Recent advances in celiac disease.World journal of gastroenterology · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Hugh James FreemanDepartment of Medicine, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T1W5, Canada. hugfree@shaw.ca
University of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Celiac disease has been reported in up to 2% of some European populations. A similar risk has been identified in the America and Australia where immigration of Europeans has occurred. Moreover, an increasing number of celiac disease patients are being identified in many Asian countries, including China and India. Finally, celiac disease has also been detected in Asian immigrants and their descendants to other countries, such as Canada. Within these so-called "general" celiac populations, however, there are specific high risk groups that have an even higher prevalence of celiac disease. Indeed, the single most important risk factor for celiac disease is having a first-degree relative with already-defined celiac disease, particularly a sibling. A rate up to 20% or more has been noted. Risk is even greater if a specific family has 2 siblings affected, particularly if a male carries the human leukocyte antigen-DQ2. Both structural changes in the small bowel architecture occur along with functional changes in permeability, even in asymptomatic first-degree relatives. Even if celiac disease is not evident, the risk of other autoimmune disorders seems significantly increased in first-degree relatives as well as intestinal lymphoma. Identification of celiac disease is important since recent long-term studies have shown that the mortality of celiac disease is increased, if it is unrecognized and untreated.

Indexed as

AnimalsAutoimmune DiseasesBiopsyCeliac DiseaseGenetic LinkageGenetic MarkersGenomeGenome-Wide Association StudyHLA-DQ AntigensHumansMaleMass ScreeningPrevalenceRiskRisk FactorsGenetic MarkersHLA-DQ2 antigenHLA-DQ AntigensCeliac diseaseFamilial diseaseGenome-wide association studiesGenome-wide linkage studiesHuman leukocyte antigen-DQ2Risk factorsScreening

Identifiers

PMID20397258
PMCPMC2856821
OpenAlexW2125869507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.