ArticleIntensive care medicine2010
Mechanical ventilation modulates Toll-like receptor signaling pathway in a sepsis-induced lung injury model.
Article in Intensive care medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 47 citations in OpenAlex.
- Establishing a nomogram of the risk of in-hospital mortality in children with suspected sepsis and validating the applicability of the Phoenix.BMC pediatrics · 2026Article
- Identification and Validation of Liver Transplantation-Induced Acute Lung Injury Biomarkers Using a Bioinformatics and Experimental Approach.Annals of transplantation · 2026Article
- WISP1 and TLR4 on Macrophages Contribute to Ventilator-Induced Lung Injury.Inflammation · 2020Article
- Human Adipose Tissue-Derived Stromal Cells Attenuate the Multiple Organ Injuries Induced by Sepsis and Mechanical Ventilation in Mice.Inflammation · 2019Article
- SU5416 attenuated lipopolysaccharide-induced acute lung injury in mice by modulating properties of vascular endothelial cells.Drug design, development and therapy · 2019Article
- Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-κB and A2aR Signaling in LPS-Induced THP-1 Macrophages.International journal of biological sciences · 2019Article
- Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1-αvβ5 integrin pathway in TLR4-mediated inflammation and injury.Critical care (London, England) · 2018Article
- The Role of Danger Signals in the Pathogenesis and Perpetuation of Critical Illness.American journal of respiratory and critical care medicine · 2018Review
- Systemic Inflammation and Acute-on-Chronic Liver Failure: Too Much, Not Enough.Canadian journal of gastroenterology & hepatology · 2018Review
- The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats.International journal of molecular medicine · 2016Article
- Suppressive oligonucleotides inhibit inflammation in a murine model of mechanical ventilator induced lung injury.Journal of thoracic disease · 2016Article
- Inhibition of endotoxin-induced airway epithelial cell injury by a novel family of pyrrol derivates.Laboratory investigation; a journal of technical methods and pathology · 2016Article
- [Ventilation as a trigger for organ dysfunction and sepsis].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2016Review
- Mechanical Ventilation Alters the Development of Staphylococcus aureus Pneumonia in Rabbit.PloS one · 2016Article
- Tryptase is involved in the development of early ventilator-induced pulmonary fibrosis in sepsis-induced lung injury.Critical care (London, England) · 2015Article
- Cecal ligation and puncture accelerates development of ventilator-induced lung injury.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Lung Transcriptomics during Protective Ventilatory Support in Sepsis-Induced Acute Lung Injury.PloS one · 2015Article
- Mechanical Ventilation Induces an Inflammatory Response in Preinjured Lungs in Late Phase of Sepsis.Oxidative medicine and cellular longevity · 2015Article
- Early activation of pro-fibrotic WNT5A in sepsis-induced acute lung injury.Critical care (London, England) · 2014Article
- Predictors of long-term mortality after severe sepsis in the elderly.The American journal of the medical sciences · 2014Article
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Authors and funding
9 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExperimental and clinical studies on sepsis have demonstrated activation of the innate immune response following the initial host-bacterial interaction. In addition, mechanical ventilation (MV) can induce a pulmonary inflammatory response. How these two responses interact when present simultaneously remains to be elucidated. We hypothesized that MV modulates innate host response during sepsis by influencing Toll-like receptor (TLR) signaling.
designProspective, randomized, controlled animal study. SUBJECTS: Male, septic Sprague-Dawley rats.
interventionsSepsis was induced by cecal ligation and perforation. At 18 h, surviving animals had the cecum removed and were randomized to spontaneous breathing or two strategies of MV for 4 h: high (20 ml/kg) tidal volume (V (T)) with no positive end-expiratory pressure (PEEP) versus low V (T) (6 ml/kg) plus 10 cmH(2)O PEEP. MEASUREMENTS AND MAIN
resultsHistological evaluation, TLR-2, TLR-4, inhibitory kappaB alpha (IkappaBalpha), interleukin-1 receptor-associated kinase-3 (IRAK-3) gene expression, protein levels and immunohistochemical lung localization, inflammatory cytokines gene expression, and protein serum concentrations were analyzed. MV with low V (T) plus PEEP attenuated sepsis-associated TLR-4 activation, and produced a significant decrease of IRAK-3 gene expression and protein levels, a significant increase of IkappaBalpha, and a decrease in lung gene expression and serum levels of cytokines. High-V (T) MV caused a significant increase of TLR-4 and IRAK-3 protein levels, lung and systemic cytokines, and mortality, and a significant decrease of IkappaBalpha.
conclusionsOur findings suggest a novel mechanism that could partially explain how MV modulates the innate immune response in the lung by interfering with cellular signaling pathways that are activated in response to pathogens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.