ReviewApplied microbiology and biotechnology2010
Synthetic biology approaches in drug discovery and pharmaceutical biotechnology.
Review in Applied microbiology and biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Green Drug Discovery: Leveraging Biodiversity for Sustainable Pharmaceutical Solutions.Chemistry & biodiversity · 2026Review
- Natural Bioactive Molecules: An Alternative Approach to the Treatment and Control of COVID-19.International journal of molecular sciences · 2021Review
- Need for speed: evaluation of dilute and shoot-mass spectrometry for accelerated metabolic phenotyping in bioprocess development.Analytical and bioanalytical chemistry · 2021Article
- Current approaches for target-specific drug discovery using natural compounds against SARS-CoV-2 infection.Virus research · 2020Review
- Catalytic Upgrading in Bacteria-Compatible Conditions via a Biocompatible Aldol Condensation.ACS sustainable chemistry & engineering · 2016Article
- CRISPR-Cas9: Tool for Qualitative and Quantitative Plant Genome Editing.Frontiers in plant science · 2016Review
- Emerging concepts promising new horizons for marine biodiscovery and synthetic biology.Marine drugs · 2015Review
- Establishing Chlamydomonas reinhardtii as an industrial biotechnology host.The Plant journal : for cell and molecular biology · 2015Review
- Challenges for the European governance of synthetic biology for human health.Life sciences, society and policy · 2014Article
- Artificially constructed quorum-sensing circuits are used for subtle control of bacterial population density.PloS one · 2014Article
- Databases of the thiotemplate modular systems (CSDB) and their in silico recombinants (r-CSDB).Journal of industrial microbiology & biotechnology · 2013Article
- Directed evolution as a powerful synthetic biology tool.Methods (San Diego, Calif.) · 2013Article
- Synthetic genomics and synthetic biology applications between hopes and concerns.Current genomics · 2013Article
- Synergistic Synthetic Biology: Units in Concert.Frontiers in bioengineering and biotechnology · 2013Review
- Systems approaches for synthetic biology: a pathway toward mammalian design.Frontiers in physiology · 2013Article
- Unexploited therapies in breast and prostate cancer: blockade of the prolactin receptor.Trends in endocrinology and metabolism: TEM · 2010Review
- Synthetic biology: putting synthesis into biology.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthetic biology is the attempt to apply the concepts of engineering to biological systems with the aim to create organisms with new emergent properties. These organisms might have desirable novel biosynthetic capabilities, act as biosensors or help us to understand the intricacies of living systems. This approach has the potential to assist the discovery and production of pharmaceutical compounds at various stages. New sources of bioactive compounds can be created in the form of genetically encoded small molecule libraries. The recombination of individual parts has been employed to design proteins that act as biosensors, which could be used to identify and quantify molecules of interest. New biosynthetic pathways may be designed by stitching together enzymes with desired activities, and genetic code expansion can be used to introduce new functionalities into peptides and proteins to increase their chemical scope and biological stability. This review aims to give an insight into recently developed individual components and modules that might serve as parts in a synthetic biology approach to pharmaceutical biotechnology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.