ArticleClinical and translational science2008
A patient suffering from hypokalemic periodic paralysis is deficient in skeletal muscle ATP-sensitive K channels.
Article in Clinical and translational science, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Exposure to 15% oxygen in vivo up-regulates cardioprotective SUR2A without affecting ERK1/2 and AKT: a crucial role for AMPK.Journal of cellular and molecular medicine · 2017Article
- Commentary: A BK (Slo1) channel journey from molecule to physiology.Frontiers in pharmacology · 2017Article
- Regulation of myometrial contraction by ATP-sensitive potassium (KATP) channel via activation of SUR2B and Kir 6.2 in mouse.The Journal of veterinary medical science · 2016Article
- Idiopathic generalized epilepsy and hypokalemic periodic paralysis in a family of South Indian descent.Case reports in neurological medicine · 2015Article
- Real-time RT-PCR Ct values for blood GAPDH correlate with measures of vascular endothelial function in humans.Clinical and translational science · 2013Article
- Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231.BMC pharmacology & toxicology · 2013Article
- Advances in cardiac ATP-sensitive K+ channelopathies from molecules to populations.Circulation. Arrhythmia and electrophysiology · 2011Article
- Recent advances in the pathogenesis and drug action in periodic paralyses and related channelopathies.Frontiers in pharmacology · 2011Article
- Human oocytes express ATP-sensitive K(+) channels.Human reproduction (Oxford, England) · 2010Article
- Human K(ATP) channelopathies: diseases of metabolic homeostasis.Pflugers Archiv : European journal of physiology · 2010Review
- M-LDH physically associated with sarcolemmal K ATP channels mediates cytoprotection in heart embryonic H9C2 cells.The international journal of biochemistry & cell biology · 2009Article
- A dual mechanism of cytoprotection afforded by M-LDH in embryonic heart H9C2 cells.Biochimica et biophysica acta · 2009Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Hypokalemic periodic paralysis (HOPP) is a rare disease associated with attacks of muscle weakness and hypokalemia. In the present study, immunoprecipitation/Western blotting has shown that a HOPP patient was deficient in sarcolemmal K(ATP) channels. Real-time RT-PCR has revealed that HOPP has decreased mRNA levels of Kir6.2, a pore-forming K(ATP) channel subunit, without affecting the expression of other K(ATP) channel-forming proteins. Based on these findings, we conclude that HOPP could be associated with impaired expression of Kir6.2 which leads to deficiency in skeletal muscle K(ATP) channels, which may explain the symptoms and clinical signs of this disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.