ArticleOpen neuroendocrinology journal (Online)2009
The Role of the Y Chromosome in Brain Function.
Article in Open neuroendocrinology journal (Online), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
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- Maternal adverse childhood experiences and preschool children's behavioral problems: exploring mediation via an adapted measure of adult attachment pattern.Frontiers in psychology · 2025Article
- Sex-limited chromosomes and non-reproductive traits.BMC biology · 2022Review
- Analysis of Y chromosome haplogroups in Parkinson's disease.Brain communications · 2022Article
- Paternal Cannabis Exposure Prior to Mating, but Not Δ9-Tetrahydrocannabinol, Elicits Deficits in Dopaminergic Synaptic Activity in the Offspring.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Complete androgen insensitivity syndrome (CAIS) and eating disorders: a case report.Eating and weight disorders : EWD · 2021Article
- A paradigmatic autistic phenotype associated with loss of PCDH11Y and NLGN4Y genes.BMC medical genomics · 2021Article
- Sex differences in neuro(auto)immunity and chronic sciatic nerve pain.Biology of sex differences · 2020Review
- Article
- Sex: A Significant Risk Factor for Neurodevelopmental and Neurodegenerative Disorders.Brain sciences · 2018Review
- Mice With Partial Deletion of Y-Heterochromatin Exhibits Stress Vulnerability.Frontiers in behavioral neuroscience · 2018Article
- Sexual congruency in the connectome and translatome of VTA dopamine neurons.Scientific reports · 2017Article
- Genes, Gender, Environment, and Novel Functions of Estrogen Receptor Beta in the Susceptibility to Neurodevelopmental Disorders.Brain sciences · 2017Review
- Sex chromosome abnormalities and psychiatric diseases.Oncotarget · 2017Review
- Attention deficit hyperactivity disorder (ADHD) in phenotypically similar neurogenetic conditions: Turner syndrome and the RASopathies.Journal of neurodevelopmental disorders · 2017Review
- Masculinised Behaviour of XY Females in a Mammal with Naturally Occuring Sex Reversal.Scientific reports · 2016Article
- Spatial sexual dimorphism of X and Y homolog gene expression in the human central nervous system during early male development.Biology of sex differences · 2016Article
- Mutational landscape of the human Y chromosome-linked genes and loci in patients with hypogonadism.Journal of genetics · 2015Article
- Effects of Prenatal Testosterone Exposure on Sexually Dimorphic Gene Expression in the Neonatal Mouse Cortex and Hippocampus.Journal of steroids & hormonal science · 2014Article
- Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In mammals, sex differences are evident in many aspects of brain development, brain function and behaviour. Ultimately, such differences must arise from the differential sex chromosome complements in males and females: males inherit a single X chromosome and a Y chromosome, whilst females inherit two X chromosomes. One possible mechanism for sexual differentiation of the brain is via male-limited expression of genes on the small Y chromosome. Many Y-linked genes have been implicated in the development of the testes, and therefore could theoretically contribute to sexual differentiation of the brain indirectly, through influencing gonadal hormone production. Alternatively, Y-linked genes that are expressed in the brain could directly influence neural masculinisation. The present paper reviews evidence from human genetic studies and animal models for Y-linked effects (both direct and indirect) on neurodevelopment, brain function and behaviour. Besides enhancing our knowledge of the mechanisms underlying mammalian neural sexual differentiation, studies geared towards understanding the role of the Y chromosome in brain function will help to elucidate the molecular basis of sex-biased neuropsychiatric disorders, allowing for more selective sex-specific therapies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.