ArticleJournal of biomedicine & biotechnology2010
Mechanical and electrophysiological properties of the sarcolemma of muscle fibers in two murine models of muscle dystrophy: col6a1-/- and mdx.
Article in Journal of biomedicine & biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Cytosolic CaBiophysical reports · 2023Article
- Three-dimensional mechanical characterization of murine skeletal muscle using quantitative micro-elastography.Biomedical optics express · 2022Article
- An AFM-Based Nanomechanical Study of Ovarian Tissues with Pathological Conditions.International journal of nanomedicine · 2020Article
- Development of a novel multiphysical approach for the characterization of mechanical properties of musculotendinous tissues.Scientific reports · 2019Article
- NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice.eLife · 2018Article
- Collagen VI Null Mice as a Model for Early Onset Muscle Decline in Aging.Frontiers in molecular neuroscience · 2017Article
- CL316,243, a β3-adrenergic receptor agonist, induces muscle hypertrophy and increased strength.Scientific reports · 2016Article
- Three-dimensional optical coherence micro-elastography of skeletal muscle tissue.Biomedical optics express · 2014Article
- Acute failure of action potential conduction in mdx muscle reveals new mechanism of contraction-induced force loss.The Journal of physiology · 2013Article
- Article
- Microtubules underlie dysfunction in duchenne muscular dystrophy.Science signaling · 2012Article
- Structural and functional evaluation of branched myofibers lacking intermediate filaments.American journal of physiology. Cell physiology · 2012Article
- Transcriptional profiling identifies differentially expressed genes in developing turkey skeletal muscle.BMC genomics · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
This study aimed to analyse the sarcolemma of Col6a1-/- fibers in comparison with wild type and mdx fibers, taken as positive control in view of the known structural and functional alterations of their membranes. Structural and mechanical properties were studied in single muscle fibers prepared from FDB muscle using atomic force microscopy (AFM) and conventional electrophysiological techniques to measure ionic conductance and capacitance. While the sarcolemma topography was preserved in both types of dystrophic fibers, membrane elasticity was significantly reduced in Col6a1-/- and increased in mdx fibers. In the membrane of Col6a1-/- fibers ionic conductance was increased likely due to an increased leakage, whereas capacitance was reduced, and the action potential (ap) depolarization rate was reduced. The picture emerging from experiments on fibers in culture was consistent with that obtained on intact freshly dissected muscle. Mdx fibers in culture showed a reduction of both membrane conductance and capacitance. In contrast, in mdx intact FDB muscle resting conductance was increased while resting potential and ap depolarization rate were reduced, likely indicating the presence of a consistent population of severely altered fibers which disappear during the culture preparation.
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