Evidence map›Paper›PMID 20395970›Full record

ReviewNature reviews. Genetics2010

Synthetic biology: applications come of age.

Ahmad S Khalil, James J Collins

Abstract readReview
In one paragraph

Review in Nature reviews. Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 505 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
505citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

505 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Review
  8. Optimized cumate toolkit for tunable protein expression duringApplied and environmental microbiology · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Stem cells in organogenesis and regeneration.Stem cell research & therapy · 2026
    Review
  16. Article
  17. Rethinking governance of synthetic cells.Frontiers in bioengineering and biotechnology · 2026
    Article
  18. Article
  19. Review
  20. Article

445 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ahmad S KhalilHoward Hughes Medical Institute, Department of Biomedical Engineering, Center for BioDynamics and Center for Advanced Biotechnology, Boston University, Boston, Massachusetts 02215, USA.
James J Collins

Funding

A Network Biology Approach to Antibiotic Action and Bacterial Defense MechanismsDP1OD003644 · OD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI COLLINS, JAMES J · 2007 to 2011
$4.1M
NIH HHS DP1 OD003644
6 · The paper itself

Abstract

Synthetic biology is bringing together engineers and biologists to design and build novel biomolecular components, networks and pathways, and to use these constructs to rewire and reprogram organisms. These re-engineered organisms will change our lives over the coming years, leading to cheaper drugs, 'green' means to fuel our cars and targeted therapies for attacking 'superbugs' and diseases, such as cancer. The de novo engineering of genetic circuits, biological modules and synthetic pathways is beginning to address these crucial problems and is being used in related practical applications.

Indexed as

Genetic EngineeringAnimalsBiocompatible MaterialsBiofuelsBiosensing TechniquesBiotechnologyDrug TherapyGene Regulatory NetworksHumansTechnology, PharmaceuticalBiocompatible MaterialsBiofuels

Identifiers

PMID20395970
PMCPMC2896386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.