ArticleObesity (Silver Spring, Md.)2010
Generation of leptin receptor bone marrow chimeras: recovery from irradiation, immune cellularity, cytokine expression, and metabolic parameters.
Article in Obesity (Silver Spring, Md.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Role of myeloid cell leptin signaling in the regulation of glucose metabolism.Scientific reports · 2021Article
- Tissue-Specific Effects of Leptin on Glucose and Lipid Metabolism.Endocrine reviews · 2021Review
- There and Back Again: Leptin Actions in White Adipose Tissue.International journal of molecular sciences · 2020Review
- Obesity: a neuroimmunometabolic perspective.Nature reviews. Endocrinology · 2020Review
- Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma.International journal of medical sciences · 2019Article
- Nutritional effects on T-cell immunometabolism.European journal of immunology · 2017Review
- Macrophage recruitment in obese adipose tissue.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2015Review
- What have we really learned about macrophage recruitment to adipose tissue?Endocrinology · 2014Article
- Leptin metabolically licenses T cells for activation to link nutrition and immunity.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Bone marrow leptin signaling mediates obesity-associated adipose tissue inflammation in male mice.Endocrinology · 2014Article
- Immunomodulation at epithelial sites by obesity and metabolic disease.Immunologic research · 2012Review
- Deficiency of ACE2 in Bone-Marrow-Derived Cells Increases Expression of TNF-α in Adipose Stromal Cells and Augments Glucose Intolerance in Obese C57BL/6 Mice.International journal of hypertension · 2012Article
- Expression of the leptin receptor outside of bone marrow-derived cells regulates tuberculosis control and lung macrophage MHC expression.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Leptin regulates appetite and metabolism but also immunity and inflammation. Although functional leptin receptors (LepR) are expressed on hematopoietic cells, the role of these receptors in regulating immune function in vivo remains controversial. To clarify this issue, we performed bone marrow (BM) transplantation between obese db/db mice, lacking LepR, and wild-type (WT) mice. Results indicate that expression of LepR on BM-derived cells directly, though partially, regulates spleen and thymus cellularity, although the environment of db mice contributes to maintaining reduced cellularity of these organs. Selective expression of LepR on BM-derived cells also modulates leptin and adiponectin levels, with induction of a more favorable adipokine environment in the WT→db/db group. However, LepR signaling in BM-derived cells is not involved in regulation of body weight (BW) and composition, glycemia, hepatosteatosis or adipose tissue inflammation, although it modulates expression of interleukin (IL)-1β in the brain. Finally, data indicate that db mice have an increased susceptibility to irradiation compared to WT mice in terms of BW loss and recovery of leukocyte counts in peripheral blood. Therefore, interpretation of results obtained using BM chimeras between WT and db mice should take into account the difference in radiation sensitivity between the two types of animals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.