ArticlePublic health genomics2010
Debating clinical utility.
Article in Public health genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- A pharmacogenetic versus a clinical algorithm for warfarin dosing.The New England journal of medicine · 2013Trial
- Beyond severity: utility as a criterion for setting the scope of RGCS.European journal of human genetics : EJHG · 2025Article
- Prognosis, treatment decision-making and value: A qualitative exploration of the emerging role of breast cancer prognostic assays.PloS one · 2025Article
- Policy-making and implementation for newborn bloodspot screening in Europe: a comparison between EURORDIS principles and UK practice.The Lancet regional health. Europe · 2023Review
- Clinical Utility of Patient-Reported Outcome Measures Used for Tendon and Nerve Transfers for Tetraplegia in New Zealand.Journal of hand surgery global online · 2023Article
- Framing the utility and potential pitfalls of relationship and identity DNA testing across United States immigration contexts.HGG advances · 2022Article
- Conceptualization of utility in translational clinical genomics research.American journal of human genetics · 2021Review
- Outcomes of prior authorization requests for genetic testing in outpatient pediatric genetics clinics.Genetics in medicine : official journal of the American College of Medical Genetics · 2021Article
- Multigene panel testing for hereditary breast and ovarian cancer in the province of Ontario.Journal of cancer research and clinical oncology · 2021Article
- Using the Delphi method to identify clinicians' perceived importance of pediatric exome sequencing results.Genetics in medicine : official journal of the American College of Medical Genetics · 2020Article
- Genome Diagnostics: Novel Strategies for Measuring Value.Journal of managed care & specialty pharmacy · 2019Article
- Clinical Utility of Advanced Microbiology Testing Tools.Journal of clinical microbiology · 2019Review
- Diagnostic exome sequencing in children: A survey of parental understanding, experience and psychological impact.Clinical genetics · 2018Article
- Evidence for Treatment-by-Biomarker interaction for FDA-approved Oncology Drugs with Required Pharmacogenomic Biomarker Testing.Scientific reports · 2017Article
- Parents' Attitudes toward Clinical Genetic Testing for Autism Spectrum Disorder-Data from a Norwegian Sample.International journal of molecular sciences · 2017Article
- Policy Making in Newborn Screening Needs a Structured and Transparent Approach.Frontiers in public health · 2017Review
- The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Review
- Experiences and attitudes of residents regarding a community-based genome cohort study in Japan: a population-based, cross-sectional study.BMC medical genomics · 2016Article
- "Is It Worth Knowing?" Focus Group Participants' Perceived Utility of Genomic Preconception Carrier Screening.Journal of genetic counseling · 2016Article
- Parents' perceptions of the usefulness of chromosomal microarray analysis for children with autism spectrum disorders.Journal of autism and developmental disorders · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The clinical utility of genetic tests is determined by the outcomes following test use. Like other measures of value, it is often contested. Stakeholders may have different views about benefits and risks and about the importance of social versus health outcomes. They also commonly disagree about the evidence needed to determine whether a test is effective in achieving a specific outcome. Questions may be presented as factual disagreements, when they are actually debates about what information matters or how facts should be interpreted and used in clinical decision-making. Defining the different issues at stake is therefore an important element of policy-making. Key issues include evidence standards for test use, and in particular, the circumstances under which prospective controlled data should be required, as well as evidence on feasibility, cost and equitable delivery of testing; the goals of population-based screening programs, and in particular, the role of social outcomes in evaluating test value; and the appropriate uses and funding of tests that inform non-medical actions. Addressing each of these issues requires attention to stakeholder values and methods for effective deliberation that incorporate consumer as well as health professional perspectives.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.