ArticleThe American journal of pathology2010
An immunocompromised murine model of chronic Bartonella infection.
Article in The American journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- The prevalence and genetic diversity of Bartonella species in wild rodents from South Korea.Scientific reports · 2025Article
- Evaluation of the available animal models forOne health (Amsterdam, Netherlands) · 2024Review
- A comparison of Bartonella henselae infection in immunocompetent and immunocompromised mice.PloS one · 2024Article
- Article
- Transmission Cycle of Tick-Borne Infections and Co-Infections, Animal Models and Diseases.Pathogens (Basel, Switzerland) · 2022Review
- What Is in a Cat Scratch? Growth ofMicroorganisms · 2021Review
- Article
- Bartonella Species, an Emerging Cause of Blood-Culture-Negative Endocarditis.Clinical microbiology reviews · 2017Review
- Novel Approach for Evaluation ofFrontiers in microbiology · 2016Article
- High prevalence and genetic heterogeneity of rodent-borne Bartonella species on Heixiazi Island, China.Applied and environmental microbiology · 2015Article
- Oroya fever and verruga peruana: bartonelloses unique to South America.PLoS neglected tropical diseases · 2014Review
- Bartonella infection in immunocompromised hosts: immunology of vascular infection and vasoproliferation.Clinical & developmental immunology · 2012Review
- Vector competence of the tick Ixodes ricinus for transmission of Bartonella birtlesii.PLoS neglected tropical diseases · 2011Article
- The First Report of Bartonella quintana Immune Reconstitution Inflammatory Syndrome Complicated by Jarisch-Herxheimer Reaction.Journal of the International Association of Providers of AIDS CareArticle
- The trimeric autotransporter adhesin BadA is required for in vitro biofilm formation byNPJ biofilms and microbiomesArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bartonella are ubiquitous gram-negative pathogens that cause chronic blood stream infections in mammals. Two species most often responsible for human infection, B. henselae and B. quintana, cause prolonged febrile illness in immunocompetent hosts, known as cat scratch disease and trench fever, respectively. Fascinatingly, in immunocompromised hosts, these organisms also induce new blood vessel formation leading to the formation of angioproliferative tumors, a disease process named bacillary angiomatosis. In addition, they cause an endothelial-lined cystic disease in the liver known as bacillary peliosis. Unfortunately, there are as yet no completely satisfying small animal models for exploring these unique human pathologies, as neither species appears able to sustain infection in small animal models. Therefore, we investigated the potential use of other Bartonella species for their ability to recapitulate human pathologies in an immunodeficient murine host. Here, we demonstrate the ability of Bartonella taylorii to cause chronic infection in SCID/BEIGE mice. In this model, Bartonella grows in extracellular aggregates, embedded within collagen matrix, similar to previous observations in cat scratch disease, bacillary peliosis, and bacillary angiomatosis. Interestingly, despite overwhelming infection later in disease, evidence for significant intracellular replication in endothelial or other cell types was not evident. We believe that this new model will provide an important new tool for investigation of Bartonella-host interaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.