ArticleGenes & development2010
A wheel of time: the circadian clock, nuclear receptors, and physiology.
Article in Genes & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Review
- Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive NaFrontiers in physiology · 2019Article
- The sweet tooth of the circadian clock.Biochemical Society transactions · 2017Review
- ADORA2b Signaling in Cardioprotection.Journal of nature and science · 2016Article
- Cracking the O-GlcNAc code in metabolism.Trends in endocrinology and metabolism: TEM · 2013Review
- O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination.Cell metabolism · 2013Article
- Nature's Timepiece-Molecular Coordination of Metabolism and Its Impact on Aging.International journal of molecular sciences · 2013Article
- The role of circadian clocks in metabolic disease.The Yale journal of biology and medicine · 2012Review
- The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis.Cell death and differentiation · 2012Article
- Persistent polar depletion of stratospheric ozone and emergent mechanisms of ultraviolet radiation-mediated health dysregulation.Reviews on environmental health · 2012Review
- Genomic convergence among ERRα, PROX1, and BMAL1 in the control of metabolic clock outputs.PLoS genetics · 2011Article
- Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver.PLoS biology · 2011Article
- Nuclear receptors and AMPK: resetting metabolism.Cold Spring Harbor symposia on quantitative biology · 2011Review
- Aging and the Mammalian regulatory triumvirate.Aging and disease · 2010Article
Corrections and comments
- Comment on
Authors and funding
1 author.
Funding
Abstract
It is a long-standing view that the circadian clock functions to proactively align internal physiology with the 24-h rotation of the earth. Recent studies, including one by Schmutz and colleagues (pp. 345-357) in the February 15, 2010, issue of Genes & Development, delineate strikingly complex connections between molecular clocks and nuclear receptor signaling pathways, implying the existence of a large-scale circadian regulatory network coordinating a diverse array of physiological processes to maintain dynamic homeostasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.