Evidence map›Paper›PMID 20395341›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2010

Imaging atherosclerosis and vulnerable plaque.

Mehran M Sadeghi, David K Glover, Gregory M Lanza, Zahi A Fayad, Lynne L Johnson

Abstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Computed Tomography and Coronary Plaque Analysis.Tomography (Ann Arbor, Mich.) · 2025
    Review
  2. Peptide Receptor Radionuclide Therapy UsingDiagnostics (Basel, Switzerland) · 2024
    Article
  3. Article
  4. Invasive electrochemical impedance spectroscopy with phase delay for experimental atherosclerosis phenotyping.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  10. Article
  11. Review
  12. Validation of Ultrasound Super-Resolution Imaging of Vasa Vasorum in Rabbit Atherosclerotic Plaques.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020
    Article
  13. Dynamic whole-body PET imaging: principles, potentials and applications.European journal of nuclear medicine and molecular imaging · 2019
    Review
  14. Targeting therapeutics to endothelium: are we there yet?Drug delivery and translational research · 2018
    Review
  15. Contrast media & molecular imaging · 2018
    Article
  16. Article
  17. Article
  18. Article
  19. Vasa vasorum in atherosclerosis and clinical significance.International journal of molecular sciences · 2015
    Review
  20. (18)F-FDG PET and vascular inflammation: time to refine the paradigm?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mehran M SadeghiYale University School of Medicine, New Haven, Connecticut, USA.
David K Glover
Gregory M Lanza
Zahi A Fayad
Lynne L Johnson

Funding

SOCS-1 and endothelial dysfunction in graft arteriosclerosisP01HL070295 · NHLBI · YALE UNIVERSITY · PI POBER, JORDAN S · 2001 to 2010
$17.9M
UIUC Nanomaterials & Nanofabrication for Targeting CancerU54CA119342 · NCI · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2005 to 2009
$16.5M
METHODS IN MOLECULAR IMAGING AND TARGETED THERAPEUTICSR01HL073646 · NHLBI · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2004 to 2016
$13.7M
MR/PET Imaging of coronary atherosclerosisR01HL071021 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FAYAD, ZAHI A. · 2002 to 2019
$7.8M
Theranostic HDL nanoparticles for inflammatory macrophages in atherosclerosisR01EB009638 · NIBIB · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAYAD, ZAHI A. · 2009 to 2016
$4.6M
Fibrin-Specific Thrombolytic Nanoparticles for Acute StrokeR01NS059302 · NINDS · WASHINGTON UNIVERSITY · PI LANZA, GREGORY M · 2007 to 2011
$1.7M
Novel Imaging to Predict Cardiovascular Events in DiabetesR01HL092989 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FARKOUH, MICHAEL E, FAYAD, ZAHI A. · 2009 to 2010
$1.6M
Molecular Imaging of Vascular RemodelingR01HL085093 · NHLBI · YALE UNIVERSITY · PI SADEGHI, MEHRAN M · 2007 to 2011
$1.6M
NCI NIH HHS U54 CA119342NHLBI NIH HHS P01 HL070295NHLBI NIH HHS R01 HL071021NHLBI NIH HHS R01 HL073646NHLBI NIH HHS R01 HL085093NHLBI NIH HHS R01 HL092989NIBIB NIH HHS R01 EB009638NINDS NIH HHS R01 NS059302
6 · The paper itself

Abstract

Identifying patients at high risk for an acute cardiovascular event such as myocardial infarction or stroke and assessing the total atherosclerotic burden are clinically important. Currently available imaging modalities can delineate vascular wall anatomy and, with novel probes, target biologic processes important in plaque evolution and plaque stability. Expansion of the vessel wall involving remodeling of the extracellular matrix can be imaged, as can angiogenesis of the vasa vasorum, plaque inflammation, and fibrin deposits on early nonocclusive vascular thrombosis. Several imaging platforms are available for targeted vascular imaging to acquire information on both anatomy and pathobiology in the same imaging session using either hybrid technology (nuclear combined with CT) or MRI combined with novel probes targeting processes identified by molecular biology to be of importance. This article will discuss the current state of the art of these modalities and challenges to clinical translation.

Indexed as

AnimalsAtherosclerosisClinical Trials as TopicContrast MediaExtracellular MatrixFerric CompoundsFluorodeoxyglucose F18HumansInflammationMagnetic Resonance ImagingNanoparticlesNeovascularization, PathologicRiskThrombosisTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedContrast MediaFerric Compoundsferric oxideFluorodeoxyglucose F18

Identifiers

PMID20395341
PMCPMC2911776

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.