ArticleThe Journal of biological chemistry2010
Damaged DNA-binding protein 1 (DDB1) interacts with Cdh1 and modulates the function of APC/CCdh1.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells.Theranostics · 2022Article
- Every protagonist has a sidekick: Structural aspects of human xeroderma pigmentosum-binding proteins in nucleotide excision repair.Protein science : a publication of the Protein Society · 2021Review
- LncRNA PANDAR regulates the G1/S transition of breast cancer cells by suppressing p16(INK4A) expression.Scientific reports · 2016Article
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- Regulation of SOX10 stability via ubiquitination-mediated degradation by Fbxw7α modulates melanoma cell migration.Oncotarget · 2015Article
- TEL2 suppresses metastasis by down-regulating SERPINE1 in nasopharyngeal carcinoma.Oncotarget · 2015Article
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- Targeting the anaphase-promoting complex/cyclosome (APC/C)- bromodomain containing 7 (BRD7) pathway for human osteosarcoma.Oncotarget · 2014Article
- miR-148b functions as a tumor suppressor in non-small cell lung cancer by targeting carcinoembryonic antigen (CEA).International journal of clinical and experimental medicine · 2014Article
- CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.The Journal of cell biology · 2013Article
- hSSB1 regulates both the stability and the transcriptional activity of p53.Cell research · 2013Article
- Human KIAA1018/FAN1 nuclease is a new mitotic substrate of APC/C(Cdh1).Chinese journal of cancer · 2012Article
- Glycogen synthase kinase-3β, NF-κB signaling, and tumorigenesis of human osteosarcoma.Journal of the National Cancer Institute · 2012Article
- Arabidopsis WD repeat domain55 Interacts with DNA damaged binding protein1 and is required for apical patterning in the embryo.The Plant cell · 2012Article
- miR-124 suppresses multiple steps of breast cancer metastasis by targeting a cohort of pro-metastatic genes in vitro.Chinese journal of cancer · 2011Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
APC/C(Cdh1) plays a key role in mitotic exit and has essential targets in the G(1) phase; however, these mechanisms are poorly understood. In this report, we provide evidence that damaged DNA-binding protein 1 (DDB1) is capable of binding the WD40 domains of Cdh1, but not of Cdc20, through its BPA and BPC domains. Moreover, cells lacking DDB1 exhibit markedly elevated levels of the protein substrates of APC/C(Cdh1). Depletion of DDB1 in mitotic cells significantly delays mitotic exit, which demonstrates that the interaction between DDB1 and Cdh1 plays a critical role in regulating APC/C(Cdh1) activity. However, cells depleted of Cdh1 demonstrated no change in the UV-induced degradation of Cdt1, the main function of DDB1 as an E3 ligase. Strikingly, the APC/C(Cdh1) substrate levels are normal in cell knockdowns of Cul4A and Cul4B, which, along with DDB1, form an E3 ligase complex. This finding indicates that DDB1 modulates the function of APC/C(Cdh1) in a manner independent on the Cul4-DDB1 complex. Our results suggest that DDB1 may functionally regulate mitotic exit by modulating APC/C(Cdh1) activity. This study reveals that there may be cross-talk among DDB1, Cdh1, and Skp2 in the control of cell cycle division.
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