Evidence map›Paper›PMID 20394829›Full record

ArticleNeuroImage2010

Reduced cognitive control of response inhibition by the anterior cingulate cortex in autism spectrum disorders.

Yigal Agam, Robert M Joseph, Jason J S Barton, Dara S Manoach

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yigal AgamDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA.
Robert M Joseph
Jason J S Barton
Dara S Manoach

Funding

ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A · 1999 to 2011
$16.4M
Spatiotemporal dynamics of executive function in schizoR01MH067720 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MANOACH, DARA S · 2004 to 2011
$3.1M
Multimodal Studies of Executive Function Deficits in Autism Spectrum DisordersF32MH088081 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI AGAM, YIGAL N · 2009 to 2012
$155k
NCRR NIH HHS P41 RR014075NCRR NIH HHS P41RR14075NIMH NIH HHS F32 MH088081NIMH NIH HHS R01 MH067720NIMH NIH HHS R01 MH67720
6 · The paper itself

Abstract

Response inhibition, or the suppression of prepotent, but contextually inappropriate behaviors, is essential to adaptive, flexible responding. In autism spectrum disorders (ASD), difficulty inhibiting prepotent behaviors may contribute to restricted, repetitive behavior (RRB). Individuals with ASD consistently show deficient response inhibition while performing antisaccades, which require one to inhibit the prepotent response of looking towards a suddenly appearing stimulus (i.e., a prosaccade), and to substitute a gaze in the opposite direction. Here, we used fMRI to identify the neural correlates of this deficit. We focused on two regions that are critical for saccadic inhibition: the frontal eye field (FEF), the key cortical region for generating volitional saccades, and the dorsal anterior cingulate cortex (dACC), which is thought to exert top-down control on the FEF. We also compared ASD and control groups on the functional connectivity of the dACC and FEF during saccadic performance. In the context of an increased antisaccade error rate, ASD participants showed decreased functional connectivity of the FEF and dACC and decreased inhibition-related activation (based on the contrast of antisaccades and prosaccades) in both regions. Decreased dACC activation correlated with a higher error rate in both groups, consistent with a role in top-down control. Within the ASD group, increased FEF activation and dACC/FEF functional connectivity were associated with more severe RRB. These findings demonstrate functional abnormalities in a circuit critical for volitional ocular motor control in ASD that may contribute to deficient response inhibition and to RRB. More generally, our findings suggest reduced cognitive control over behavior by the dACC in ASD.

Indexed as

Inhibition, PsychologicalAdultChild Development Disorders, PervasiveCognitionExecutive FunctionEye Movement MeasurementsFemaleFrontal LobeGyrus CinguliHumansInfantMagnetic Resonance ImagingMaleNeural PathwaysNeuropsychological TestsPsychomotor Performance

Identifiers

PMID20394829
PMCPMC2883672

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.