ArticleEvolution; international journal of organic evolution2010
Uncoordinated phylogeography of Borrelia burgdorferi and its tick vector, Ixodes scapularis.
Article in Evolution; international journal of organic evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- When Clades Collide: Genomic Admixture in Blacklegged Ticks (Ixodes scapularis) From the Great Plains.Molecular ecology · 2026Article
- Genetic and Landscape Connectivity of Blacklegged Ticks During Range Expansion in Select States of the Midwestern USA.Ecology and evolution · 2025Article
- Genetic diversity and phylogeographic relationships of Dermacentor variabilis (Acari: Ixodidae) within an established population in southern Manitoba (Canada), and the prevalence of Rickettsia montanensis and Francisella-like endosymbionts.Journal of medical entomology · 2025Article
- Changes in the geographic distribution of the blacklegged tick, Ixodes scapularis, in the United States.Ticks and tick-borne diseases · 2023Review
- Infectious Disease Sensitivity to Climate and Other Driver-Pressure Changes: Research Effort and Gaps for Lyme Disease and Cryptosporidiosis.GeoHealth · 2023Review
- Prevalence of Borrelia burgdorferi and diversity of its outer surface protein C (ospC) alleles in blacklegged ticks (Ixodes scapularis) in Delaware.Ticks and tick-borne diseases · 2023Article
- Phylogeographic reconstruction of the emergence and spread of Powassan virus in the northeastern United States.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Phylogeographic dynamics of the arthropod vector, the blacklegged tick (Ixodes scapularis).Parasites & vectors · 2022Article
- The evolution of hard tick-borne relapsing fever borreliae is correlated with vector species rather than geographical distance.BMC ecology and evolution · 2021Article
- Spatio-temporal variation in environmental features predicts the distribution and abundance of Ixodes scapularis.International journal for parasitology · 2021Article
- Impact of prior and projected climate change on US Lyme disease incidence.Global change biology · 2021Article
- Evolutionary Genetics ofCurrent issues in molecular biology · 2021Review
- Evolutionary ecology of Lyme Borrelia.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020Review
- Genetic Melting Pot in Blacklegged Ticks at the Northern Edge of their Expansion Front.The Journal of heredity · 2020Article
- Northern and southern blacklegged (deer) ticks are genetically distinct with different histories and Lyme spirochete infection rates.Scientific reports · 2020Article
- Comparative vector competence of North American Lyme disease vectors.Parasites & vectors · 2020Article
- Genomic insights into the ancient spread of Lyme disease across North America.Nature ecology & evolution · 2017Article
- A Roadmap for Tick-Borne Flavivirus Research in the "Omics" Era.Frontiers in cellular and infection microbiology · 2017Review
- TRANSLATING ECOLOGY, PHYSIOLOGY, BIOCHEMISTRY, AND POPULATION GENETICS RESEARCH TO MEET THE CHALLENGE OF TICK AND TICK-BORNE DISEASES IN NORTH AMERICA.Archives of insect biochemistry and physiology · 2016Review
- County-Scale Distribution of Ixodes scapularis and Ixodes pacificus (Acari: Ixodidae) in the Continental United States.Journal of medical entomology · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Vector-borne microbes necessarily co-occur with their hosts and vectors, but the degree to which they share common evolutionary or biogeographic histories remains unexplored. We examine the congruity of the evolutionary and biogeographic histories of the bacterium and vector of the Lyme disease system, the most prevalent vector-borne disease in North America. In the eastern and midwestern US, Ixodes scapularis ticks are the primary vectors of Borrelia burgdorferi, the bacterium that causes Lyme disease. Our phylogeographic and demographic analyses of the 16S mitochondrial rDNA suggest that northern I. scapularis populations originated from very few migrants from the southeastern US that expanded rapidly in the Northeast and subsequently in the Midwest after the recession of the Pleistocene ice sheets. Despite this historical gene flow, current tick migration is restricted even between proximal sites within regions. In contrast, B. burgdorferi suffers no barriers to gene flow within the northeastern and midwestern regions but shows clear interregional migration barriers. Despite the intimate association of B. burgdorferi and I. scapularis, the population structure, evolutionary history, and historical biogeography of the pathogen are all contrary to its arthropod vector. In the case of Lyme disease, movements of infected vertebrate hosts may play a larger role in the contemporary expansion and homogenization of the pathogen than the movement of tick vectors whose populations continue to bear the historical signature of climate-induced range shifts.
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