ArticleSleep2010
Chronic caffeine treatment prevents sleep deprivation-induced impairment of cognitive function and synaptic plasticity.
Article in Sleep, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 155 citations in OpenAlex.
- Early Life Sleep Deprivation and Brain Development: Insights From Human and Animal Studies.Frontiers in neuroscience · 2022Pooled it
- Trial
- Caffeine reverses sleep deprivation-induced synaptic and social memory deficits via adenosine receptor modulation in the male mouse hippocampal CA2 region.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Tirzepatide attenuates neurotoxicity by suppressing inflammation, apoptosis and restoring neurotrophin expression in an Alzheimer's disease-like rat model.Metabolic brain disease · 2026Article
- Nobiletin (NOB) nanoparticles ameliorate chronic paradoxical sleep deprivation (PSD)-induced cognitive deficits in rats.Cell death discovery · 2025Article
- Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation.Archives of pharmacal research · 2025Review
- A 108-h total sleep deprivation did not impair fur seal performance in delayed matching to sample task.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer's disease neuropathology in adult zebrafish.Journal of neuroinflammation · 2023Article
- Effects of enriched environment on the expression of β-amyloid and transport-related proteins LRP1 and RAGE in chronic sleep-deprived mice.Translational neuroscience · 2023Article
- The protective effect of melatonin on chronic paradoxical sleep deprivation induced metabolic and memory deficit in rats.International journal of physiology, pathophysiology and pharmacology · 2023Article
- Intraperitoneal ozone injection prevents REM sleep deprivation - induced spatial learning and memory deficits by suppressing the expression ofIranian journal of basic medical sciences · 2022Article
- Jiedu Tongluo Granules Ameliorates Post-stroke Depression Rat ModelFrontiers in pharmacology · 2021Article
- Bioactive Compounds and Traditional Herbal Medicine: Promising Approaches for the Treatment of Dementia.Degenerative neurological and neuromuscular disease · 2021Review
- Caffeine has a dual influence on NMDA receptor-mediated glutamatergic transmission at the hippocampus.Purinergic signalling · 2020Article
- Caffeine as a promotor of sexual development in sterile Queensland fruit fly males.Scientific reports · 2020Article
- Performance on the mouse vibration actuating search task is compromised by sleep deprivation.Journal of neurophysiology · 2020Article
- Cellular and Molecular Differences Between Area CA1 and the Dentate Gyrus of the Hippocampus.Molecular neurobiology · 2019Review
- Early Life Sleep Deprivation: Role of Oxido-Inflammatory Processes.Neuroscience · 2019Article
- Caffeine Prevents Memory Impairment Induced by Hyperhomocysteinemia.Journal of molecular neuroscience : MN · 2018Article
- Exercise as a Positive Modulator of Brain Function.Molecular neurobiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesThis study was undertaken to provide a detailed account of the effect of chronic treatment with a small dose of caffeine on the deleterious effects of sleep loss on brain function in rats. EXPERIMENTAL
designWe investigated the effects of chronic (4 weeks) caffeine treatment (0.3 g/L in drinking water) on memory impairment in acutely (24 h) sleep-deprived adult male Wistar rats. Sleep deprivation was induced using the modified multiple platform model. The effects of caffeine on sleep deprivation-induced hippocampus-dependent learning and memory deficits were studied by 3 approaches: learning and memory performance in the radial arm water maze task, electrophysiological recording of early long-term potentiation (E-LTP) in area CA1 of the hippocampus, and levels of memory- and synaptic plasticity-related signaling molecules after E-LTP induction. MEASUREMENT AND
resultsThe results showed that chronic caffeine treatment prevented impairment of hippocampus-dependent learning, shortterm memory and E-LTP of area CA1 in the sleep-deprived rats. In correlation, chronic caffeine treatment prevented sleep deprivation-associated decrease in the levels of phosphorylated calcium/calmodulin-dependent protein kinase II (P-CaMKII) during expression of E-LTP.
conclusionsThe results suggest that long-term use of a low dose of caffeine prevents impairment of short-term memory and E-LTP in acutely sleep-deprived rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.