ArticleThe Journal of comparative neurology2010
Language-related Cntnap2 gene is differentially expressed in sexually dimorphic song nuclei essential for vocal learning in songbirds.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- CNTNAP2: isoform- and context-specific functions in neurological disorders and cancer.Frontiers in cellular neuroscience · 2026Review
- Characterizing maternal isolation-induced ultrasonic vocalizations in a gene-environment interaction rat model for autism.Genes, brain, and behavior · 2023Article
- Sex and gender in neurodevelopmental conditions.Nature reviews. Neurology · 2023Review
- Article
- GABAFrontiers in integrative neuroscience · 2021Article
- ZEBrA: Zebra finch Expression Brain Atlas-A resource for comparative molecular neuroanatomy and brain evolution studies.The Journal of comparative neurology · 2020Article
- Mapping the distribution of language related genes FoxP1, FoxP2, and CntnaP2 in the brains of vocal learning bat species.The Journal of comparative neurology · 2018Article
- Dysregulation of Parvalbumin Expression in theFrontiers in molecular neuroscience · 2018Article
- IntragenicMolecular syndromology · 2017Review
- Protein-Protein Interaction Among the FoxP Family Members and their Regulation of Two Target Genes,Frontiers in molecular neuroscience · 2017Article
- Dynamic gene expression in the song system of zebra finches during the song learning period.Developmental neurobiology · 2015Article
- Connecting the CNTNAP2 Networks with Neurodevelopmental Disorders.Molecular syndromology · 2015Review
- Shining a light on CNTNAP2: complex functions to complex disorders.European journal of human genetics : EJHG · 2014Review
- Genetic aspects of autism spectrum disorders: insights from animal models.Frontiers in cellular neuroscience · 2014Review
- Distribution of language-related Cntnap2 protein in neural circuits critical for vocal learning.The Journal of comparative neurology · 2014Article
- Translating birdsong: songbirds as a model for basic and applied medical research.Annual review of neuroscience · 2013Review
- What does CNTNAP2 reveal about autism spectrum disorder?Trends in molecular medicine · 2012Review
- Evo-devo, deep homology and FoxP2: implications for the evolution of speech and language.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Modeling autistic features in animals.Pediatric research · 2011Review
- Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Multiple studies, involving distinct clinical populations, implicate contactin associated protein-like 2 (CNTNAP2) in aspects of language development and performance. While CNTNAP2 is broadly distributed in developing rodent brain, it shows a striking gradient of frontal cortical enrichment in developing human brain, consistent with a role in patterning circuits that subserve higher cognition and language. To test the hypothesis that CNTNAP2 may be important for learned vocal communication in additional species, we employed in situ hybridization to characterize transcript distribution in the zebra finch, an experimentally tractable songbird for which the neural substrate of this behavior is well established. Consistent with an important role in learned vocalization, Cntnap2 was enriched or diminished in key song control nuclei relative to adjacent brain tissue. Importantly, this punctuated expression was observed in males, but not females, in accord with the sexual dimorphism of neural circuitry and vocal learning in this species. Ongoing functional work will provide important insights into the relationship between Cntnap2 and vocal communication in songbirds and thereby clarify mechanisms at play in disorders of human cognition and language.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.